Evidence map›Paper›PMID 30249247›Full record

SynthesisBMC medicine2018

Musculoskeletal conditions may increase the risk of chronic disease: a systematic review and meta-analysis of cohort studies.

Amanda Williams, Steven J Kamper, John H Wiggers, Kate M O'Brien, Hopin Lee, Luke Wolfenden, Sze Lin Yoong, Emma Robson, James H McAuley, Jan Hartvigsen and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 15 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 15 syntheses or guidelines pooled it, 311 citations in OpenAlex.

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  13. Exercise training and depression and anxiety in musculoskeletal pain patients: a meta-analysis of randomized control trials.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2023
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  20. Hip Joint Loading During Walking Is Associated With Cartilage Defect Severity in Young Adult Football Players With Hip/Groin Pain.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Amanda WilliamsSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia. amanda.j.williams@hnehealth.nsw.gov.au.ORCID 0000-0002-9213-9178
Steven J KamperCentre for Pain, Health and Lifestyle, Ourimbah, NSW, Australia.
John H WiggersSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Kate M O'BrienSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Hopin LeeSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Luke WolfendenSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Sze Lin YoongSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Emma RobsonSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
James H McAuleyCentre for Pain, Health and Lifestyle, Ourimbah, NSW, Australia.
Jan HartvigsenDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Christopher M WilliamsSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia.
Hunter New England Local Health District · AUNeuroscience Research Australia · AUNew South Wales Department of Health · AUNuffield Orthopaedic Centre · GBThe University of Sydney · AUUniversity of Newcastle Australia · AUUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic diseases and musculoskeletal conditions have a significant global burden and frequently co-occur. Musculoskeletal conditions may contribute to the development of chronic disease; however, this has not been systematically synthesised. We aimed to investigate whether the most common musculoskeletal conditions, namely neck or back pain or osteoarthritis of the knee or hip, contribute to the development of chronic disease.

methodsWe searched CINAHL, Embase, Medline, Medline in Process, PsycINFO, Scopus and Web of Science to February 8, 2018, for cohort studies reporting adjusted estimates of the association between baseline musculoskeletal conditions (neck or back pain or osteoarthritis of the knee or hip) and subsequent diagnosis of a chronic disease (cardiovascular disease, cancer, diabetes, chronic respiratory disease or obesity). Two independent reviewers performed data extraction and assessed study quality. Adjusted hazard ratios were pooled using the generic inverse variance method in random effect models, regardless of the type of musculoskeletal condition or chronic disease. PROSPERO: CRD42016039519.

resultsThere were 13 cohort studies following 3,086,612 people. In the primary meta-analysis of adjusted estimates, osteoarthritis (n = 8 studies) and back pain (n = 2) were the exposures and cardiovascular disease (n = 8), cancer (n = 1) and diabetes (n = 1) were the outcomes. Pooled adjusted estimates from these 10 studies showed that people with a musculoskeletal condition have a 17% increase in the rate of developing a chronic disease compared to people without (hazard ratio 1.17, 95% confidence interval 1.13-1.22; I

conclusionsThis meta-analysis found that musculoskeletal conditions may increase the risk of chronic disease. In particular, osteoarthritis appears to increase the risk of developing cardiovascular disease. Prevention and early treatment of musculoskeletal conditions and targeting associated chronic disease risk factors in people with long standing musculoskeletal conditions may play a role in preventing other chronic diseases. However, a greater understanding about why musculoskeletal conditions may increase the risk of chronic disease is needed.

Indexed as

Chronic DiseaseCohort StudiesHumansMaleMusculoskeletal DiseasesRiskBack painChronic diseaseMeta-analysisOsteoarthritis

Identifiers

PMID30249247
PMCPMC6154805
OpenAlexW2891162085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.