Evidence map›Paper›PMID 30249063›Full record

ArticleProteomes2018

Proteases Shape the

Raj Luxmi, Crysten Blaby-Haas, Dhivya Kumar, Navin Rauniyar, Stephen M King, Richard E Mains, Betty A Eipper

Open access · goldAbstract read
In one paragraph

Article in Proteomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Regulated processing and secretion of a peptide precursor in cilia.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Review
  8. Premetazoan Origin of Neuropeptide Signaling.Molecular biology and evolution · 2022
    Article
  9. Article
  10. High-throughput selection of cells based on accumulated growth and division using PicoShell particles.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Physiological signaling in the absence of amidated peptides.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Raj LuxmiDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA. luxmi@uchc.edu.
Crysten Blaby-HaasDepartment of Biology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. mains@uchc.edu.
Dhivya KumarDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305, USA. dhivya.kumar@ucsf.edu.
Navin RauniyarW.M. Keck Biotechnology Resource Laboratory, Yale University, New Haven, CT 06511-6624, USA. cblaby@bnl.gov.
Stephen M KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305, USA. king@uchc.edu.
Richard E MainsDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA. navin.rauniyar@yale.edu.
Betty A EipperDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA. eipper@uchc.edu.
UConn Health · USBrookhaven National Laboratory · USW. M. Keck Foundation · US

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
MOLECULAR ANALYSIS OF FLAGELLAR DYNEIN FUNCTIONR01GM051293 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KING, STEPHEN M · 1995 to 2020
$6.9M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR01DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, KING, STEPHEN M · 1986 to 2017
$6.4M
National Institutes of Health 1S100DOD018034National Institutes of Health DA018343National Institutes of Health DK032949National Institutes of Health GM051293NIDA NIH HHS P30 DA018343NIDDK NIH HHS R01 DK032949NIGMS NIH HHS R01 GM051293U.S. Department of Energy Office of Science and Office of Biological and Environmental Research
6 · The paper itself

Abstract

The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic common ancestor (LECA). We identified prototypical neuropeptide precursors and essential peptide processing enzymes (subtilisin-like prohormone convertases and carboxypeptidase B-like enzymes) in the

Indexed as

carboxypeptidaseciliamatingmatrix metalloproteinasepeptidylglycine α-amidating monooxygenasepherophorinprohormone convertasesignal peptidesubtilisin

Identifiers

PMID30249063
PMCPMC6313938
OpenAlexW2890867761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.