Evidence map›Paper›PMID 30249039›Full record

ArticleToxins2018

The Impact of Uremic Toxicity Induced Inflammatory Response on the Cardiovascular Burden in Chronic Kidney Disease.

Ligia Maria Claro, Andrea N Moreno-Amaral, Ana Carolina Gadotti, Carla J Dolenga, Lia S Nakao, Marina L V Azevedo, Lucia de Noronha, Marcia Olandoski, Thyago P de Moraes, Andréa E M Stinghen and 1 more

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04247867 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Combination of Medium Cut-off Dialyzer Membrane and Diet Modification to Alleviate Residual Uremic Syndrome of Dialysis Patients

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2020 to 2022Enrolled50ConditionsEnd Stage Renal Disease, Haemodialysis, Diet, HealthyArmsmedium cut-off (MCO) dialysis membrane, Dietary fiber mixture (Plantago Psyllium and Inulin), Sodium propionate
NCT04260412 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effect of Combining Medium Cut Off Polyarylethersulfone-polyvinylpyrrolidone Dialysis Membrane and Diet Modification on Reducing of Inflammation Response

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2020 to 2022Enrolled50ConditionsEnd Stage Renal Disease, Haemodialysis, Diet, Healthy, Chronic InflammationArmsmedium cut-off (MCO) dialysis membrane, Dietary fiber mixture (Plantago Psyllium 69% and Inulin 30%), Sodium propionate
NCT04527640 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis

TypeinterventionalSponsorIndonesia UniversityRan2020 to 2021Enrolled60ConditionsConstipation, End Stage Renal Disease on DialysisArmsSynbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg, Placebo
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
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  5. Article
  6. Review
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  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Blood-Brain Barrier Biomarkers before and after Kidney Transplantation.International journal of molecular sciences · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Immunosenescence: an unexplored role in glomerulonephritis.Clinical & translational immunology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ligia Maria ClaroGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. lmclaro@gmail.com.
Andrea N Moreno-AmaralGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. deamoreno@gmail.com.
Ana Carolina GadottiGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. ana_raixu3@hotmail.com.
Carla J DolengaBasic Pathology Department, Universidade Federal do Paraná, Curitiba, PR 80050-540, Brazil. carla.vet10@gmail.com.
Lia S NakaoBasic Pathology Department, Universidade Federal do Paraná, Curitiba, PR 80050-540, Brazil. lia.nakao@ufpr.br.
Marina L V AzevedoGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. malu_tu@yahoo.com.br.
Lucia de NoronhaGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. lnno.noronha@gmail.com.
Marcia OlandoskiGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. bio.estatistica@pucpr.br.
Thyago P de MoraesGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. thyago.moraes@pucpr.br.
Andréa E M StinghenBasic Pathology Department, Universidade Federal do Paraná, Curitiba, PR 80050-540, Brazil. andreastinghen@ufpr.br.ORCID 0000-0001-8595-5321
Roberto Pécoits-FilhoGraduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil. r.pecoits@pucpr.br.
Pontifícia Universidade Católica do Paraná · BRUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uremic toxin (UT) retention in chronic kidney disease (CKD) affects biological systems. We aimed to identify the associations between UT, inflammatory biomarkers and biomarkers of the uremic cardiovascular response (BUCVR) and their impact on cardiovascular status as well as their roles as predictors of outcome in CKD patients. CKD patients stages 3, 4 and 5 (

Indexed as

AdultAgedBiomarkersCardiovascular DiseasesCD36 AntigensCresolsCytokinesFemaleGlomerular Filtration RateHumansIndicanIndoleacetic AcidsInflammationMaleMiddle AgedRenal Artery4-cresol sulfateBiomarkersCD36 AntigensCD36 protein, humanCresolsCytokinesIndicanindoleacetic acidIndoleacetic AcidsSulfuric Acid EstersToxins, Biologicalfractalkine (CX3CL1)fractalkine receptor (CX3CR1)inflammatory biomarkerssCD36sRAGEuremic toxins

Identifiers

PMID30249039
PMCPMC6215310
OpenAlexW2892633805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.