Evidence map›Paper›PMID 30249015›Full record

ArticleInternational journal of molecular sciences2018

Bioactive Peptides from Germinated Soybean with Anti-Diabetic Potential by Inhibition of Dipeptidyl Peptidase-IV, α-Amylase, and α-Glucosidase Enzymes.

Marcela González-Montoya, Blanca Hernández-Ledesma, Rosalva Mora-Escobedo, Cristina Martínez-Villaluenga

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 198 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Marcela González-MontoyaEscuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional. Campus Zacatenco, Unidad Profesional "Adolfo López Mateos", Calle Wilfrido Massieu esquina Cda. Manuel Stampa. C.P, Ciudad de México 07738, Mexico. marceglezmon@gmail.com.
Blanca Hernández-LedesmaInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI UAM+CSIC), Nicolás Cabrera 9, 28049 Madrid, Spain. b.hernandez@csic.es.
Rosalva Mora-EscobedoEscuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional. Campus Zacatenco, Unidad Profesional "Adolfo López Mateos", Calle Wilfrido Massieu esquina Cda. Manuel Stampa. C.P, Ciudad de México 07738, Mexico. rosalmorae@gmail.com.
Cristina Martínez-VillaluengaInstitute of Food Science, Technology and Nutrition (ICTAN-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. c.m.villaluenga@csic.es.ORCID 0000-0002-1155-6464
Instituto Politécnico Nacional · MXInstituto de Ciencia y Tecnología de Alimentos y Nutrición · ESInstituto de Investigación en Ciencias de la Alimentación · ES

Funding

Consejo Nacional de Ciencia y Tecnología 242860Consejo Nacional de Ciencia y Tecnología 291062Ministerio de Economía, Industria y Competitividad, Gobierno de España AGL2017-83718-RMinisterio de Economía y Competitividad AGL2015-66886-R
6 · The paper itself

Abstract

Functional foods containing peptides offer the possibility to modulate the absorption of sugars and insulin levels to prevent diabetes. This study investigates the potential of germinated soybean peptides to modulate postprandial glycaemic response through inhibition of dipeptidyl peptidase IV (DPP-IV), salivary α-amylase, and intestinal α-glucosidases. A protein isolate from soybean sprouts was digested by pepsin and pancreatin. Protein digest and peptide fractions obtained by ultrafiltration (<5, 5⁻10 and >10 kDa) and subsequent semipreparative reverse phase liquid chromatography (F1, F2, F3, and F4) were screened for in vitro inhibition of DPP-IV, α-amylase, maltase, and sucrase activities. Protein digest inhibited DPP-IV (IC

Indexed as

Germinationalpha-Amylasesalpha-GlucosidasesDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsGene Expression Regulation, EnzymologicGlycine maxHumansHypoglycemic AgentsPeptide FragmentsPlant Extractsalpha-Amylasesalpha-GlucosidasesDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsHypoglycemic AgentsPeptide FragmentsPlant Extractsdipeptidyl peptidasegastrointestinal digestiongerminated soybeaninhibitorspeptidesα-amylaseα-glucosidase

Identifiers

PMID30249015
PMCPMC6213256
OpenAlexW2891082191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.