ArticleInternational journal of molecular sciences2018
Tuning Nanopore Diameter of Titanium Surfaces to Improve Human Gingival Fibroblast Response.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- The impact of anodization modification on titanium interaction with human osteoblasts and fibroblasts (in vitro study).PloS one · 2025Article
- Nanostructured Implant-Tissue Interface Assessment Using a Three-Dimensional Gingival Tissue Equivalent.ACS omega · 2024Article
- Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.International journal of nanomedicine · 2024Article
- Piranha-etched titanium nanostructure reduces biofilm formation in vitro.Clinical oral investigations · 2023Article
- Graphene Oxide Loaded on TiOInternational journal of molecular sciences · 2022Article
- In vitro behaviour of human gingival fibroblasts cultured on 3D-printed titanium alloy with hydrogenated TiOJournal of materials science. Materials in medicine · 2022Article
- Influence of Bioinspired Lithium-Doped Titanium Implants on Gingival Fibroblast Bioactivity and Biofilm Adhesion.Nanomaterials (Basel, Switzerland) · 2021Article
- Enhanced Human Gingival Fibroblast Response and ReducedBioMed research international · 2020Article
- Oriented Cell Alignment Induced by a Nanostructured Titanium Surface Enhances Expression of Cell Differentiation Markers.Nanomaterials (Basel, Switzerland) · 2019Article
- Molecular-Level Interactions between Engineered Materials and Cells.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The aim of this study was to determine the optimal nanopore diameter of titanium nanostructured surfaces to improve human gingival fibroblast (hGF) response, with the purpose of promoting gingiva integration to dental implant abutments. Two TiO₂ nanoporous groups with different diameters (NP-S ~48 nm and NP-B ~74 nm) were grown on Ti foils using an organic electrolyte containing fluoride by electrochemical oxidation, varying the applied voltage and the interelectrode spacing. The surfaces were characterized by scanning electron microscope (SEM), atomic force microscopy (AFM), and contact angle. The hGF were cultured onto the different surfaces, and metabolic activity, cytotoxicity, cell adhesion, and gene expression were analyzed. Bigger porous diameters (NP-B) were obtained by increasing the voltage used during anodization. To obtain the smallest diameter (NP-S), apart from lowering the voltage, a lower interelectrode spacing was needed. The greatest surface area and number of peaks was found for NP-B, despite these samples not being the roughest as defined by R
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