Evidence map›Paper›PMID 30248972›Full record

ArticleNutrients2018

Human Breast Milk NMR Metabolomic Profile across Specific Geographical Locations and Its Association with the Milk Microbiota.

Carlos Gómez-Gallego, Jose Manuel Morales, Daniel Monleón, Elloise du Toit, Himanshu Kumar, Kaisa M Linderborg, Yumei Zhang, Baoru Yang, Erika Isolauri, Seppo Salminen and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Trial
  2. Article
  3. Automated, targeted, NMR spectral profiling of human breast milk.Metabolomics : Official journal of the Metabolomic Society · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carlos Gómez-GallegoFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014 Turku, Finland. cargom@utu.fi.ORCID 0000-0003-0219-1827
Jose Manuel MoralesLaboratory of Metabolomics, Institute of Health Research-INCLIVA, 46010 Valencia, Spain. J.Manuel.Morales@uv.es.ORCID 0000-0002-4404-6735
Daniel MonleónLaboratory of Metabolomics, Institute of Health Research-INCLIVA, 46010 Valencia, Spain. daniel.monleon@uv.es.
Elloise du ToitDivision of Medical Microbiology, Department of Pathology, University of Cape Town, 7925 Cape Town, South Africa. elloisedutoit@gmail.com.
Himanshu KumarFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014 Turku, Finland. kumar.himanshu@utu.fi.
Kaisa M LinderborgFood Chemistry and Food Development, Department of Biochemistry, University of Turku, 20014 Turku, Finland. kamayl@utu.fi.
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, 100191 Beijing, China. zhangyumei@bjmu.edu.cn.ORCID 0000-0002-0103-7900
Baoru YangFood Chemistry and Food Development, Department of Biochemistry, University of Turku, 20014 Turku, Finland. bayang@utu.fi.
Erika IsolauriDepartment of Paediatrics, University of Turku and Turku University Hospital, 20520 Turku, Finland. eriiso@utu.fi.
Seppo SalminenFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014 Turku, Finland. sepsal@utu.fi.ORCID 0000-0002-9737-7642
Maria Carmen ColladoFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014 Turku, Finland. mcolam@iata.csic.es.ORCID 0000-0002-6204-4864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of human breast milk is highly variable, and it can be influenced by genetics, diet, lifestyle, and other environmental factors. This study aimed to investigate the impact of geographical location and mode of delivery on the nuclear magnetic resonance spectroscopy (NMR) metabolic profile of breast milk and its relationship with the milk microbiome. Human milk metabolic and microbiota profiles were determined using NMR and 16S rRNA gene sequencing, respectively, in 79 healthy women from Finland, Spain, South Africa, and China. Up to 68 metabolites, including amino acids, oligosaccharides, and fatty acid-associated metabolites, were identified in the milk NMR spectra. The metabolite profiles showed significant differences between geographical locations, with significant differences (

Indexed as

MetabolomeMicrobiotaActinobacteriaAdultAmino AcidsBacillusBacteriaCarboxylic AcidsChinaCholesterol, LDLDelivery, ObstetricFemaleFinlandHumansMetabolomicsMilk, HumanAmino AcidsCarboxylic AcidsCholesterol, LDLOligosaccharidesRiboflavinUreacaesarean sectionhuman milkmetabolitesmicrobiomemode of deliveryproton nuclear magnetic resonance

Identifiers

PMID30248972
PMCPMC6213536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.