ArticleMolecules (Basel, Switzerland)2018
Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Polysaccharide Composition of Dietary Fiber During Raspberry and Blackberry Juice Production.Molecules (Basel, Switzerland) · 2025Article
- An Overview of Antitumour Activity of Polysaccharides.Molecules (Basel, Switzerland) · 2022Review
- Antiproliferative and Pro-Apoptotic Effects of a Phenolic-Rich Extract fromMolecules (Basel, Switzerland) · 2022Article
- Polysaccharides as Potential Anti-tumor Biomacromolecules -A Review.Frontiers in nutrition · 2022Review
- Structural Elucidation, Modification, and Structure-Activity Relationship of Polysaccharides in Chinese Herbs: A Review.Frontiers in nutrition · 2022Review
- Pharmacological Effects of Guava (International journal of molecular sciences · 2021Article
- Division of labor in honey bee gut microbiota for plant polysaccharide digestion.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Preparation and Structure Analysis Methods of Natural Polysaccharides of Plants and Fungi: A Review of Recent Development.Molecules (Basel, Switzerland) · 2019Review
- Extraction, Structural Characterization, and Biological Functions ofBiomolecules · 2019Review
- Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft GrowthEvidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Modern studies have shown that pollen has a certain role in the treatment of prostate-related diseases. In the present study, pollen polysaccharides from Chinese wolfberry (WPPs) were extracted by hot-water extraction and ethanol precipitation, further purified by chromatography on a DEAE-cellulose column and Sephadex G-100 column. Homogeneous polysaccharide CF1 of WPPS was obtained, the molecular weight of which was estimated to be 1540.10 ± 48.78 kDa by HPGPC-ELSD. HPLC with PMP derivatization analysis indicated that the monosaccharide compositions of CF1 were mannose, glucuronic acid, galacturonic acid, xylose, galactose, arabinose, and trehalose, in a molar ratio of 0.68:0.59:0.27:0.24:0.22:0.67:0.08. The antitumor effects of CF1 upon MTT, Tunel assay and flow cytometry assay were investigated in vitro. The results showed that CF1 exhibited a dose-dependent antiproliferative effect, with an IC50 value of 374.11 μg/mL against DU145 prostate cancer cells. Tunel assay and flow cytometry assay showed that the antitumor activity of CF1 was related to apoptosis in vitro. The present study suggested that the CF1 of WPPs might be a potential source of antitumor functional food or agent.
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