Evidence map›Paper›PMID 30248928›Full record

ArticleToxins2018

Characterization of Chicken-Derived Single Chain Antibody Fragments against Venom of

Chi-Hsin Lee, Sy-Jye Leu, Yu-Ching Lee, Chia-I Liu, Liang-Tzung Lin, Pharaoh Fellow Mwale, Jen-Ron Chiang, Bor-Yu Tsai, Chi-Ching Chen, Ching-Sheng Hung and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Avian Antibodies as Potential Therapeutic Tools.Antibodies (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Phage display-derived alpaca nanobodies as potential therapeutics forApplied and environmental microbiology · 2024
    Article
  4. Review
  5. IgYs: on her majesty's secret service.Frontiers in immunology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. In Vitro Characterization of Neutralizing Hen Antibodies toInternational journal of molecular sciences · 2021
    Article
  10. Chicken antibodies against venom proteins ofThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  11. Article
  12. Expression, Purification, and Characterization of Anti-International journal of molecular sciences · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Chi-Hsin LeeSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. chihsine@msn.com.
Sy-Jye LeuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. cmbsycl@tmu.edu.tw.
Yu-Ching LeeThe Center of Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan. ycl@tmu.edu.tw.
Chia-I LiuSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. chliu@tmu.edu.tw.
Liang-Tzung LinGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.
Pharaoh Fellow MwaleSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. pmwale@medcol.mw.
Jen-Ron ChiangCenter for Research, Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei 11561, Taiwan. jrc@cdc.gov.tw.ORCID 0000-0002-7111-7279
Bor-Yu TsaiNavi Bio-Therapeutics Inc., Taipei 10351, Taiwan. boryutsai@navibio.com.tw.
Chi-Ching ChenDepartment of Pathology and Laboratory Medicine, Landseed Hospital, Taoyuan 32449, Taiwan. chen3971@landseed.com.tw.
Ching-Sheng HungDepartment of Laboratory Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan. oryx@w.tmu.edu.tw.
Yi-Yuan YangSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. yangyuan@tmu.edu.tw.ORCID 0000-0003-2534-8436
Taipei Medical University · TWLandseed Hospital · TWMinistry of Health and Welfare · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional, horse-derived antivenin is currently the most efficient treatment against snake bites. However, it is costly and has unpredictable side effects. Thus, alternative, cost-effective strategies for producing antivenin are needed. In this study, we immunized hens with inactivated NNA venom proteins from the cobra

Indexed as

Naja najaAnimalsAntiveninsChickensElapid VenomsFemaleImmunoglobulinsMice, Inbred ICRReptilian ProteinsSingle-Chain AntibodiesSnake BitesAntiveninsElapid VenomsIgYImmunoglobulinsReptilian ProteinsSingle-Chain AntibodiesIgY antibodiesNaja naja atra (NNA)phage display technologysingle-chain variable fragment (scFv) antibodyvenom proteins

Identifiers

PMID30248928
PMCPMC6215181
OpenAlexW2891026587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.