Evidence map›Paper›PMID 30248915›Full record

ReviewNutrients2018

The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine.

Kyle Southward, Kay Rutherfurd-Markwick, Claire Badenhorst, Ajmol Ali

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  15. Can 3 mg·kgNutrients · 2021
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  16. Effects of acute ingestion of caffeinated chewing gum on performance in elite judo athletes.Journal of the International Society of Sports Nutrition · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kyle SouthwardSchool of Sport, Exercise and Nutrition, Massey University, North Shore Mail Centre, Private Bag 102 904, Auckland 0745, New Zealand. K.A.Southward@massey.ac.nz.
Kay Rutherfurd-MarkwickSchool of Health Sciences, Massey University, Auckland 0745, New Zealand. K.J.Rutherfurd@massey.ac.nz.
Claire BadenhorstSchool of Sport, Exercise and Nutrition, Massey University, North Shore Mail Centre, Private Bag 102 904, Auckland 0745, New Zealand. C.Badenhorst@massey.ac.nz.
Ajmol AliSchool of Sport, Exercise and Nutrition, Massey University, North Shore Mail Centre, Private Bag 102 904, Auckland 0745, New Zealand. a.ali@massey.ac.nz.ORCID 0000-0002-6093-1435
Massey University · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caffeine use is widespread among athletes following its removal from the World Anti-Doping Agency banned list, with approximately 75% of competitive athletes using caffeine. While literature supports that caffeine has a small positive ergogenic effect for most forms of sports and exercise, there exists a significant amount of inter-individual difference in the response to caffeine ingestion and the subsequent effect on exercise performance. In this narrative review, we discuss some of the potential mechanisms and focus on the role that genetics has in these differences. CYP1A2 and ADORA2A are two of the genes which are thought to have the largest impact on the ergogenicity of caffeine. CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety. The effects of CYP1A2 and ADORA2A genes on responses to caffeine will be discussed in detail and an overview of the current literature will be presented. The role of these two genes may explain a large portion of the inter-individual variance reported by studies following caffeine ingestion. Elucidating the extent to which these genes moderate responses to caffeine during exercise will ensure caffeine supplementation programs can be tailored to individual athletes in order to maximize the potential ergogenic effect.

Indexed as

AnxietyAthletesAthletic PerformanceCaffeineCentral Nervous System StimulantsCytochrome P-450 CYP1A2Dietary SupplementsDoping in SportsExerciseHumansIndividualityPerformance-Enhancing SubstancesPhysical EndurancePrecision MedicineReceptor, Adenosine A2AADORA2A protein, humanCaffeineCentral Nervous System StimulantsCYP1A2 protein, humanCytochrome P-450 CYP1A2Performance-Enhancing SubstancesReceptor, Adenosine A2AADORA2Acaffeine metabolismCYP1A2pharmacological ergogenic aidtime trial performance

Identifiers

PMID30248915
PMCPMC6213712
OpenAlexW2892135436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.