Evidence map›Paper›PMID 30248646›Full record

ArticleBiomaterials2018

3D printed biofunctionalized scaffolds for microfracture repair of cartilage defects.

Ting Guo, Maeesha Noshin, Hannah B Baker, Evin Taskoy, Sean J Meredith, Qinggong Tang, Julia P Ringel, Max J Lerman, Yu Chen, Jonathan D Packer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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  16. bioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting GuoFischell Department of Bioengineering, University of Maryland, College Park, MD USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD USA.
Maeesha NoshinFischell Department of Bioengineering, University of Maryland, College Park, MD USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD USA.
Hannah B BakerFischell Department of Bioengineering, University of Maryland, College Park, MD USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD USA.
Evin TaskoyDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD USA.
Sean J MeredithDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD USA.
Qinggong TangFischell Department of Bioengineering, University of Maryland, College Park, MD USA.
Julia P RingelFischell Department of Bioengineering, University of Maryland, College Park, MD USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD USA.
Max J LermanCenter for Engineering Complex Tissues, University of Maryland, College Park, MD USA; Department of Materials Science and Engineering, University of Maryland, College Park, MD USA; Surface and Trace Chemical Analysis Group, Materials Measurement Lab, National Institute of Standards and Technology, Gaithersburg, MD USA.
Yu ChenFischell Department of Bioengineering, University of Maryland, College Park, MD USA.
Jonathan D PackerDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD USA.
John P FisherFischell Department of Bioengineering, University of Maryland, College Park, MD USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD USA. Electronic address: jpfisher@umd.edu.

Funding

Training and Dissemination CoreP41EB023833 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI MIKOS, ANTONIOS G. · 2017 to 2021
$6.2M
NIBIB NIH HHS P41 EB023833
6 · The paper itself

Abstract

While articular cartilage defects affect millions of people worldwide from adolescents to adults, the repair of articular cartilage defects still remains challenging due to the limited endogenous regeneration of the tissue and poor integration with implants. In this study, we developed a 3D-printed scaffold functionalized with aggrecan that supports the cellular fraction of bone marrow released from microfracture, a widely used clinical procedure, and demonstrated tremendous improvement of regenerated cartilage tissue quality and joint function in a lapine model. Optical coherence tomography (OCT) revealed doubled thickness of the regenerated cartilage tissue in the group treated with our aggrecan functionalized scaffold compared to standard microfracture treatment. H&E staining showed 366 ± 95 chondrocytes present in the unit area of cartilage layer with the support of bioactive scaffold, while conventional microfracture group showed only 112 ± 26 chondrocytes. The expression of type II collagen appeared almost 10 times higher with our approach compared to normal microfracture, indicating the potential to overcome the fibro-cartilage formation associated with the current microfracture approach. The therapeutic effect was also evaluated at joint function level. The mobility was evaluated using a modified Basso, Beattie and Bresnahan (BBB) scale. While the defect control group showed no movement improvement over the course of study, all experimental groups showed a trend of increasing scores over time. The present work developed an effective method to regenerate critical articular defects by combining a 3D-printed therapeutic scaffold with the microfracture surgical procedure. This biofunctionalized acellular scaffold has great potential to be applied as a supplement for traditional microfracture to improve the quality of cartilage regeneration in a cost and labor effective way.

Indexed as

AggrecansAnimalsBioprintingCartilage, ArticularCell AdhesionCell LineChondrocytesChondrogenesisFemaleFractures, StressHumansImmobilized ProteinsPrinting, Three-DimensionalRabbitsTissue ScaffoldsAggrecansImmobilized ProteinsAggrecanArticular cartilageCustom fabricationExtrusion 3D printingMicrofracturePoly(l-lactide-co-ε-caprolactone)Scaffold

Identifiers

PMID30248646
PMCPMC6186501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.