Evidence map›Paper›PMID 30248575›Full record

ArticleCell calcium2018

Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease.

Patrick Toglia, Angelo Demuro, Don-On Daniel Mak, Ghanim Ullah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. The role of IPFrontiers in computational neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Patrick TogliaDepartment of Physics, University of South Florida, Tampa, FL 33620, USA.
Angelo DemuroDepartment of Neurobiology and Behavior and Physiology and Biophysics, University of California, Irvine, CA 92697, USA.
Don-On Daniel MakDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ghanim UllahDepartment of Physics, University of South Florida, Tampa, FL 33620, USA. Electronic address: gullah@usf.edu.
University of South Florida · USUniversity of California, Irvine · USUniversity of Pennsylvania · US

Funding

Multi-scale observation and modeling of IP3/Ca signalingR01GM065830 · NIGMS · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI MAK, DON-ON DANIEL, PARKER, IAN · 2002 to 2017
$10.7M
A multi-scale data-driven model of the Abeta pore function and Ca2+ toxicity in Alzheimer's diseaseR01AG053988 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI DEMURO, ANGELO, ULLAH, GHANIM · 2016 to 2020
$2.1M
NIA NIH HHS R01 AG053988NIGMS NIH HHS R01 GM065830
6 · The paper itself

Abstract

Intracellular accumulation of oligomeric forms of β amyloid (Aβ) are now believed to play a key role in the earliest phase of Alzheimer's disease (AD) as their rise correlates well with the early symptoms of the disease. Extensive evidence points to impaired neuronal Ca

Indexed as

Data AnalysisModels, BiologicalAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCalciumInositol 1,4,5-Trisphosphate ReceptorsMitochondriaOptical ImagingPatch-Clamp TechniquesXenopus laevisAmyloid beta-PeptidesCalciumInositol 1,4,5-Trisphosphate ReceptorsAlzheimer's diseaseCa(2+) dyshomeostasisIntracellular β amyloidMitochondrial dysfunction

Identifiers

PMID30248575
PMCPMC6289702
OpenAlexW2889974497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.