Evidence map›Paper›PMID 30248310›Full record

ArticleAmerican journal of ophthalmology2019

A Population-Based, Case-Control Evaluation of the Association Between Hormonal Contraceptives and Idiopathic Intracranial Hypertension.

Khin P Kilgore, Michael S Lee, Jacqueline A Leavitt, Ryan D Frank, Collin M McClelland, John J Chen

Registry-linked trialAbstract read
In one paragraph

Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06913712 (Evolution of Body Mass Index in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment. Retrospective and Prospective Study), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06913712 recruitingnot on this mapstarted 2024, after this paper: background citation

Evolution of Body Mass Index in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment. Retrospective and Prospective Study

TypeobservationalSponsorUniversity of ValenciaRan2024 to 2028Enrolled25ConditionsIdiopathic Intracranial Hypertension (IIH)ArmsWeight loss without pharmacotherapy
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Visual outcomes of idiopathic intracranial hypertension in a neuro-ophthalmology clinic in Jeddah, Saudi Arabia.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Khin P KilgoreCollege of Medicine, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Michael S LeeDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Jacqueline A LeavittDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Ryan D FrankDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Collin M McClellandDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
John J ChenDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: chen.john@mayo.edu.
Mayo Clinic · USUniversity of Minnesota · USMayo Clinic in Florida · US

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

purposeTo determine if the use of oral contraceptive pills (OCP) and other hormonal contraceptives are associated with a higher incidence of idiopathic intracranial hypertension (IIH).

designRetrospective, population-based, case-control study.

methodsSetting: Female IIH patients evaluated between January 1, 1990, and December 31, 2016 were identified using the Rochester Epidemiology Project (REP), a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. STUDY POPULATION: Fifty-three female residents of Olmsted County diagnosed with IIH between 15 and 45 years of age. The use of OCPs and other hormonal contraceptives was compared to controls matched for age, sex, and body mass index. Interventions/Exposures: Hormonal contraceptives.

main outcome measureOdds of developing IIH.

resultsOf the 53 women diagnosed with IIH between 15 and 45 years of age, 11 (20.8%) had used hormonal contraceptives within ≤30 days of the date of IIH diagnosis, in contrast to 30 (31.3%) among the control patients. The odds ratio of hormonal contraceptive use and IIH was 0.55 (95% conficence interval [CI]: 0.24-1.23, P = .146). The odds ratio of OCP use was 0.52 (95% CI: 0.20-1.34, P = .174).

conclusionsOCP and other hormonal contraceptives were not significantly associated with a higher incidence of IIH, arguing against the need for women with IIH to discontinue their use.

Indexed as

AdolescentAdultCase-Control StudiesContraceptive AgentsFemaleHumansIncidenceMiddle AgedMinnesotaOdds RatioPseudotumor CerebriRetrospective StudiesRisk FactorsYoung AdultContraceptive Agents

Identifiers

PMID30248310
PMCPMC6291342
OpenAlexW2894191905

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.