ArticleAutism research : official journal of the International Society for Autism Research2018
Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort.
Article in Autism research : official journal of the International Society for Autism Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Altered leptin level in autism spectrum disorder and meta-analysis of adipokines.BMC psychiatry · 2024Pooled it
- The early life growth of head circumference, weight, and height in infants with autism spectrum disorders: a systematic review.BMC pediatrics · 2023Pooled it
- Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta-Analysis.Obesity (Silver Spring, Md.) · 2020Pooled it
- Maternal excessive gestational weight gain as a risk factor for autism spectrum disorder in offspring: a systematic review.BMC pregnancy and childbirth · 2020Pooled it
- Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Genetic Variations and Serum Levels of Leptin and Ghrelin in Autism Spectrum Disorder.Psychiatry and clinical psychopharmacology · 2024Article
- Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review.Journal of personalized medicine · 2024Review
- Early Life Origins of Neurodevelopmental Disabilities in the Boston Birth Cohort: Research findings and future directions.Precision nutrition · 2024Article
- Brief Report: Plasma Leptin and Mealtime Feeding Behaviors Among Children with Autism Spectrum Disorder: A Pilot Study.Journal of autism and developmental disorders · 2023Article
- Peripubertal Alterations of Leptin Levels in Patients with Autism Spectrum Disorder and Elevated or Normal Body Weight.International journal of molecular sciences · 2023Article
- The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence.Frontiers in endocrinology · 2023Review
- Maternal Western-style diet reduces social engagement and increases idiosyncratic behavior in Japanese macaque offspring.Brain, behavior, and immunity · 2022Article
- Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.International journal of environmental research and public health · 2022Article
- Maternal Midpregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorders: A Prenatal Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Serum adiponectin levels are reduced in autism spectrum disorder and association with severity of symptoms.Metabolic brain disease · 2021Article
- Assessment of autism-relevant behaviors in C57BKS/J leptin receptor deficient mice.Hormones and behavior · 2021Article
- Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2021Article
- Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children.Frontiers in psychiatry · 2021Article
- A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder.The American journal of clinical nutrition · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Leptin is a proinflammatory cytokine that plays an important role in energy homeostasis. Emerging evidence suggests that leptin levels are altered in children with autism spectrum disorder (ASD); however, this has not been studied prospectively. Rapid growth during infancy and early childhood has been implicated in ASD, but the evidence is inconsistent. As leptin is involved in growth and is a potential risk factor for ASD, we explored the associations between (a) cord, early childhood leptin and ASD; and (b) birth weight for gestational age, early childhood weight gain, and ASD. We also assessed the mediating role of leptin in the relationship between weight gain during infancy and ASD. This study was conducted in a sample of 822 subjects from the Boston Birth Cohort. ASD was defined from diagnostic codes in electronic medical records. Extremely rapid weight gain during infancy was associated with a greater ASD risk and this persisted after adjusting for potential confounders (aOR: 3.11; 95% CI: 1.37, 7.07). Similarly, children that had higher plasma leptin levels, prior to ASD diagnosis, had an increased ASD risk in both unadjusted and adjusted models (aOR: 7.87; 95% CI: 2.06, 30.04). Further, early childhood leptin indirectly mediated the relationship between rapid weight gain and ASD. No associations were found between birth weight for gestational age, cord leptin and risk of ASD. Our findings provide a basis to further explore whether the combination of early life growth pattern and a biomarker such as leptin can predict ASD earlier. Autism Res 2018, 11: 1416-1431. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Is early life growth and a biomarker leptin related to ASD risk? To answer this question, we followed 822 children from birth and found that those who gained weight very quickly in infancy, had higher leptin levels in early childhood, had a greater chance of later ASD diagnosis. More research is needed to see if infant's weight gain pattern along with a biomarker (such as leptin) can be used to identify children with ASD sooner.
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Registered trials
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