ArticlePloS one2018
Cortical reorganization after cochlear implantation for adults with single-sided deafness.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Speech in noise prediction by use of cortical auditory evoked potentials in normal hearing and sensorineural hearing loss: a systematic review.Frontiers in neuroscience · 2026Pooled it
- Pooled it
- Outcomes of anatomy based planning in cochlear implantation: a meta-analysis of advancing precision otologic medicine.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Extending the Indications of Cochlear Implantation in Adults with Single-Sided Deafness. A Comprehensive Review.Journal of personalized medicine · 2026Review
- Article
- Incomplete binaural restoration in single-sided deafness treated with cochlear implants: insights from compensatory head-orienting behaviors.Frontiers in neuroscience · 2026Article
- Auditory Cortical Plasticity in Patients with Single-Sided Deafness Before and After Cochlear Implantation.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Direct Elicitation of Cortical Auditory Evoked Potentials by Electrical Stimulation and Their Use to Verify the Most Comfortable Level of Stimulation in Cochlear Implant Users.Audiology & neuro-otology · 2023Article
- Side-of-Implantation Effect on Functional Asymmetry in the Auditory Cortex of Single-Sided Deaf Cochlear-Implant Users.Brain topography · 2022Article
- Cochlear Implants in Single-Sided Deafness. Comparison Between Children and Adult Populations With Post-lingually Acquired Severe to Profound Hearing Loss.Frontiers in neurology · 2021Article
- The Listening Network and Cochlear Implant Benefits in Hearing-Impaired Adults.Frontiers in aging neuroscience · 2021Article
- Changes in Speech-Related Brain Activity During Adaptation to Electro-Acoustic Hearing.Frontiers in neurology · 2020Article
- Article
- Development of cortical auditory responses to speech in noise in unilaterally deaf adults following cochlear implantation.PloS one · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults with single sided deafness (SSD) have lost binaural function, which limits sound source localization, speech understanding in noise, and quality of life. For SSD patients, restoration of bilateral auditory input is possible only with a cochlear implant (CI). In this study, cortical auditory evoked potentials (CAEPs) and behavioral performance were measured in left-implanted (SSD-CI-L) and right-implanted (SSD-CI-R) patients before and after cochlear implantation. We hypothesized that improvements in behavioral performance would be accompanied by changes in CAEPs after cochlear implantation.
designProspective longitudinal study.
settingTertiary referral center.
methodNine right-handed adult SSD CI patients participated in the study. CAEPs were recorded before cochlear implantation and at 6 and 12 months post-implantation. CAEPs were elicited using speech stimuli (/ba/) delivered in sound field at 70 dBA. Global field power (GFP) latency and amplitude were calculated for P1, N1 and P2 peaks at each test session. CAEP were analyzed at frontocentral (Cz) and temporal (P7, P8, T7 and T8) and mastoid electrodes (M1 and M2) contralateral to the CI ear. Behavioral measures (sentence recognition in noise, with and without spatial cues) were collected at the same test sessions as for CAEPs. Speech performance and CAEPs were also measured in a control group of normal-hearing (NH) subjects.
resultsWhile increased N1 amplitude was observed in the scalp potential maps for GFP and Cz for SSD-CI-L patients after implantation, the changes were not statistically significant. Peak CAEP amplitude at electrodes to contralateral to the CI ear increased after cochlear implantation for all SSD-CI patients, but significant increases were observed only for mastoid sites. Peak latencies for some components at temporal and mastoid sites remained significantly longer than for the NH control group, even after cochlear implantation. For SSD-CI-R patients, P2 peak amplitude for baseline GFP and Cz was significantly lower than for the NH control group. A significant improvement for speech understanding in noise was observed at 12 months post-implantation when speech was presented to the CI ear and noise to the non-implanted ear.
conclusionAfter cochlear implantation, speech understanding significantly improved when speech and noise were spatially separated. The increased N1 amplitude for SSD-CI-L patients and the increased bilateral activation for all SSD-CI patients may reflect cortical reorganization and restoration of binaural function after one year of experience with the CI. However, because of the limited number of SSD patients, significant changes in cortical activity after cochlear implantation were often difficult to observe.
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