ArticleJournal of the American Chemical Society2018
Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Repurposing trifluoromethyl copper (III) complexes for difluoromethylation of saccharides and complex alcohols.Nature communications · 2026Article
- Photochemical Cu(iii)-mediated trifluoromethylation of (hetero)arenes and biomolecules.Chemical science · 2026Article
- The Role of Electron Transfer in Copper-Mediated C(spAngewandte Chemie (International ed. in English) · 2025Article
- Red-light-mediated copper-catalyzed photoredox catalysis promotes regioselectivity switch in the difunctionalization of alkenes.Nature communications · 2024Article
- Direct Bioisostere Replacement Enabled by Metallaphotoredox Deoxydifluoromethylation.Journal of the American Chemical Society · 2024Article
- Radical Reactions in Organic Synthesis: Exploring in-, on-, and with-Water Methods.Molecules (Basel, Switzerland) · 2024Review
- Deuterated reagents in multicomponent reactions to afford deuterium-labeled products.Beilstein journal of organic chemistry · 2024Article
- Uncovering a CFAngewandte Chemie (International ed. in English) · 2023Article
- Spectral Physics of Stable Cu(III) Produced by Oxidative Addition of an Alkyl Halide.International journal of molecular sciences · 2023Article
- Tuning Benzylic C-H Functionalization of (Thio)xanthenes with Electrochemistry.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of triarylmethanes by silyl radical-mediated cross-coupling of aryl fluorides and arylmethanes.Chemical science · 2023Article
- Organo-photocatalytic C-H bond oxidation: an operationally simple and scalable method to prepare ketones with ambient air.RSC advances · 2023Article
- Synthesis of vinyl-substituted alcohols using acetylene as a C2 building block.Chemical science · 2023Article
- Iron-mediated ligand-to-metal charge transfer enables 1,2-diazidation of alkenes.Nature communications · 2022Article
- A photoinduced transient activating strategy for late-stage chemoselective C(spChemical science · 2022Article
- Deoxytrifluoromethylation of Alcohols.Journal of the American Chemical Society · 2022Article
- Radical C(sp3)-H functionalization and cross-coupling reactions.Nature reviews. Chemistry · 2022Article
- Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation.Journal of the American Chemical Society · 2022Article
- Radical-mediated vicinal addition of alkoxysulfonyl/fluorosulfonyl and trifluoromethyl groups to aryl alkyl alkynes.Chemical science · 2021Article
- Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay.Nature communications · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The installation of trifluoromethyl groups has become an essential step across a number of industries such as agrochemicals, drug discovery, and materials. Consequently, the rapid introduction of this critical functional group in a predictable fashion would benefit current practitioners in those fields. This communication describes a mild trifluoromethylation of benzylic C-H bonds with high selectivity for the least hindered hydrogen atom. The reaction provides monotrifluoromethylation and proceeds in an environmentally friendly acetone/water solvent system. The method can be used to install benzylic trifluoromethyl groups on highly functionalized drug molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.