ArticleInternational journal of cancer2019
Higher diet-dependent acid load is associated with risk of breast cancer: Findings from the sister study.
Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Association between dietary acid load and cancer risk and prognosis: An updated systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2022Pooled it
- Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Assessment of the acidifying potential of diet and sarcopenia in individuals 50 years of age or older: a cross-sectional study.BMC nutrition · 2026Article
- The association of diet-dependent acid load with gastrointestinal cancer risk in the Cancer Screenee Cohort in Korea.European journal of clinical nutrition · 2025Article
- The association between dietary acid load and odds of prostate cancer: a case-control study.Journal of health, population, and nutrition · 2025Article
- Relationship Between Dietary Acid Load and Risk of Metastatic Colorectal Cancer: A Case-Control Study.Current therapeutic research, clinical and experimental · 2025Article
- The predictive role of the total potassium intake and odds of breast cancer: a case-control study.BMC cancer · 2024Article
- Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy.Pharmaceutics · 2024Review
- Global trends of cancer: The role of diet, lifestyle, and environmental factors.Cancer innovation · 2023Review
- Review
- How Well Do Low-PRAL Diets Fare in Comparison to the 2020-2025 Dietary Guidelines for Americans?Healthcare (Basel, Switzerland) · 2023Article
- Dietary acid load and esophageal cancer risk: A case-control study.Thoracic cancer · 2022Article
- Quantifying dietary acid load in U.S. cancer survivors: an exploratory study using NHANES data.BMC nutrition · 2022Article
- Healthy eating patterns and epigenetic measures of biological age.The American journal of clinical nutrition · 2022Article
- Observational and clinical evidence that plant-based nutrition reduces dietary acid load.Journal of nutritional science · 2022Review
- Dietary Acid Load, Serum Polychlorinated Biphenyl Levels, and Mortality Following Breast Cancer in the Long Island Breast Cancer Study Project.International journal of environmental research and public health · 2021Article
- Diet-dependent acid load and the risk of colorectal cancer and adenoma: a case-control study.Public health nutrition · 2021Article
- Dietary inflammatory potential, oxidative balance score, and risk of breast cancer: Findings from the Sister Study.International journal of cancer · 2021Article
- Review
- The Molecular Effects of Dietary Acid Load on Metabolic Disease (The Cellular PasaDoble: The Fast-Paced Dance of pH Regulation).Frontiers in molecular medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Dietary factors that contribute to chronic low-grade metabolic acidosis have been linked to breast cancer risk, but to date no epidemiologic study has examined diet-dependent acid load and breast cancer. We used data from 43,570 Sister Study participants who completed a validated food frequency questionnaire at enrollment (2003-2009) and satisfied eligibility criteria. The Potential Renal Acid Load (PRAL) score was used to estimate diet-dependent acid load. Higher scores reflect greater consumption of protein and phosphorus, and lower consumption of potassium, calcium and magnesium. The association between PRAL and breast cancer was evaluated using multivariable Cox proportional hazards regression. We identified 1,614 invasive breast cancers diagnosed at least 1 year after enrollment (mean follow-up, 7.6 years). The highest PRAL quartile, reflecting greater acid-forming potential, was associated with increased risk of breast cancer (HR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.