ArticleEuropean heart journal. Cardiovascular Imaging2019
Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the coronary artery risk development in young adults (CARDIA) study.
Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis.Pediatric cardiology · 2020Trial
- Incremental predictive value of CMR phenotyping for major adverse cardiovascular events: an interpretable machine learning study from UK Biobank.Frontiers in medicine · 2026Article
- Pulmonary valve replacement-related change in biventricular global function index in repaired tetralogy of Fallot.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Long-Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30-Year Longitudinal Study.Journal of the American Heart Association · 2025Article
- Myocardial active strain energy density and contractance: novel prognostic tools for left ventricular function and cardiovascular risk.European heart journal. Imaging methods and practice · 2025Review
- Imaging and evaluation of cervicothoracic lymphatic drainage pathways in single ventricle patients with Fontan circulation using the mDixon steady state MR angiography.BMC medical imaging · 2025Article
- High afterload rather than myocardial fibrosis predicts reduced ejection fraction in severe aortic stenosis with afterload mismatch.Open heart · 2025Article
- Atherogenic ApoB-dyslipidemia, atherosclerotic cardiovascular disease, cardiac dysfunction and remodeling in high-risk young women with and without polycystic ovary syndrome: A pilot study.Frontiers in endocrinology · 2025Article
- High-Performing Fontan Patients: A Fontan Outcome Registry by Cardiac Magnetic Resonance Imaging Study.JACC. Advances · 2024Article
- Myocardial Strain Measured by Cardiac Magnetic Resonance Predicts Cardiovascular Morbidity and Death.Journal of the American College of Cardiology · 2024Article
- Association of stress hyperglycemia ratio with left ventricular function and microvascular obstruction in patients with ST-segment elevation myocardial infarction: a 3.0 T cardiac magnetic resonance study.Cardiovascular diabetology · 2024Article
- The role of cardiac remodeling associated with renal function in mediating cardiovascular event outcomes.iScience · 2024Article
- Characterization and z-score calculation of cardiovascular magnetic resonance imaging parameters in patients after the Fontan operation: A Fontan Outcome Registry using Cardiovascular Magnetic Resonance Examinations study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Utility of multimodal longitudinal imaging data for dynamic prediction of cardiovascular and renal disease: the CARDIA study.Frontiers in radiology · 2024Article
- Effects of diabetes mellitus on left ventricular function and deformation in patients with restrictive cardiomyopathies: a 3.0T CMR feature tracking study.Cardiovascular diabetology · 2023Article
- Characterizing the hypertensive cardiovascular phenotype in the UK Biobank.European heart journal. Cardiovascular Imaging · 2023Article
- Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- The role of obesity-related cardiovascular remodelling in mediating incident cardiovascular outcomes: a population-based observational study.European heart journal. Cardiovascular Imaging · 2023Observational
- Imaging Early Life Cardiovascular Phenotype.Circulation research · 2023Review
- Left ventricular global function index is associated with myocardial iron overload and heart failure in thalassemia major patients.The international journal of cardiovascular imaging · 2023Article
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14 authors.
Funding
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Abstract
aimsLeft ventricular (LV) ejection fraction (LVEF) is an extensively utilized marker of LV function that is often interpreted without recourse to alterations in LV geometry and hypertrophy. LV global function index (LVGFI) is a novel marker that incorporates LV structure in the assessment of LV cardiac performance. We evaluated the prognostic utility of LVGFI from young adulthood into middle age for incident heart failure (HF) and cardiovascular disease (CVD) in comparison to LVEF. METHODS AND
resultsIncluded were 4107 CARDIA participants with echocardiograms in Year-5 (1990-1991). LVGFI was defined as LV stroke volume/LV global volume*100, where LV global volume was the sum of the LV mean cavity volume ((LV end-diastolic volume + LV end-systolic volume)/2) and myocardial volume (LV mass/density). Adjusted Cox proportional hazard models were utilized to predict incident HF and CVD outcomes. Mean age of participants was 29.8 ± 3.7 years, 55% female, and 48.7% black. Higher body mass index [beta coefficient (B) = -0.11 standard error (SE) = 0.02, P < 0.001], higher blood pressure (B = -0.04, SE = 0.01, P < 0.01), smoking (B = -0.82, SE = 0.22, P < 0.001), male sex (P < 0.001), and black race (P < 0.001) were associated with worse LVGFI. A total of 207 incident CVD events were observed over the course of 98 035 person-years at risk. Higher LVGFI was associated with HF, hazard ratio (HR) = 0.70, 95% confidence interval (CI) (0.54-0.91), hard CVD HR = 0.83, 95% CI (0.71-0.96), and all CVD HR = 0.83, 95% CI (0.72-0.96). For HF outcomes, Harrell's C-statistic for LVGFI (0.80) was greater than LVEF (0.66).
conclusionLVGFI is a strong, independent predictor of incident HF and CVD that provides incremental prognostic value compared with LVEF. Male sex, black race, obesity, hypertension, and smoking are associated with worse LVGFI in the early adult lifespan.
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