ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Protein Intake and Functional Integrity in Aging: The Framingham Heart Study Offspring.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Low protein intake, physical activity, and physical function in European and North American community-dwelling older adults: a pooled analysis of four longitudinal aging cohorts.The American journal of clinical nutrition · 2021Pooled it
- Non-Pharmacological Interventions in Osteosarcopenia: A Systematic Review.The journal of nutrition, health & aging · 2021Pooled it
- The cost effectiveness of personalized dietary advice to increase protein intake in older adults with lower habitual protein intake: a randomized controlled trial.European journal of nutrition · 2022Trial
- Nutrition and Aging Biology: Summary of a Research Centers Collaborative Network Workshop and Research Needs.Current developments in nutrition · 2025Article
- Adherence to Mediterranean, Dietary Approaches to Stop Hypertension and Healthy Eating Indices are associated with lower risk of disability among Puerto Rican adults from the longitudinal Boston Puerto Rican Health Study.The American journal of clinical nutrition · 2024Article
- Dietary protein intake in midlife in relation to healthy aging - results from the prospective Nurses' Health Study cohort.The American journal of clinical nutrition · 2024Article
- The relationship between educational attainment, lifestyle, self-rated health, and depressive symptoms among Chinese adults: a longitudinal survey from 2012 to 2020.Frontiers in public health · 2024Article
- Nutritional importance of animal-sourced foods in a healthy diet.Frontiers in nutrition · 2024Review
- Article
- Dairy Food Intake Is Not Associated With Frailty in Adults From the Framingham Heart Study.Journal of the Academy of Nutrition and Dietetics · 2023Article
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
- Association of Plant Protein Intake with Change in Physical Performance in Chinese Community-Dwelling Older Adults.Nutrients · 2022Article
- Animal foods and mobility limitations in community-dwelling young-old adults: longitudinal analysis of the EpiDoC cohort.BMC geriatrics · 2022Article
- Oral health problems and risk of incident disability in two studies of older adults in the United Kingdom and the United States.Journal of the American Geriatrics Society · 2022Article
- Sarcopenia and bone health: new acquisitions for a firm liaison.Therapeutic advances in musculoskeletal disease · 2022Review
- Association of Dietary Protein Intake and Grip Strength Among Adults Aged 19+ Years: NHANES 2011-2014 Analysis.Frontiers in nutrition · 2022Article
- Prolonged nightly fasting and lower-extremity functioning in community-dwelling older adults.The British journal of nutrition · 2021Article
- The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society.Nutrients · 2021Review
- What do Australian adults eat for breakfast? A latent variable mixture modelling approach for understanding combinations of foods at eating occasions.The international journal of behavioral nutrition and physical activity · 2021Article
- Distribution of daily protein intake across meals and lower extremity functioning in community-dwelling Spanish older adults: a prospective cohort study.European journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHigher protein intake is linked to maintenance of muscle mass and strength, but few studies have related protein to physical function and disability in aging.
methodsIn participants of the Framingham Heart Study Offspring, we examined associations between protein intake (g/d), estimated from food frequency questionnaires, and maintenance of functional integrity, as a functional integrity score based on responses to 17 questions from Katz Activities of Daily Living, Nagi, and Rosow-Breslau questionnaires, repeated up to five times (1991/1995-2011/2014) over 23 years of follow-up. Cox proportional hazard models were used to estimate risk of incident loss of functional integrity (functional integrity score ≤ 15th percentile).
resultsIn 2,917 participants (age 54.5 [9.8] years), baseline protein intake was 77.2 (15.6) g/d. The functional integrity score (baseline, mean 98.9, range 82.4-100.0) was associated with objective performance (gait speed, grip strength) and lower odds of falls, fractures, and frailty. Across follow-up, there were 731 incident cases of loss of functional integrity. In fully adjusted models, participants in the highest category of protein intake (median 92.2 g/d) had 30% lower risk of loss of functional integrity (hazard ratio [95% confidence interval] 0.70 [0.52, 0.95], p trend = .03), versus those with the lowest intake (median 64.4 g/d). However, sex-stratified analyses indicated the association was driven by the association in women alone (hazard ratio [95% confidence interval] 0.49 [0.32, 0.74], p trend = .002) and was nonsignificant in men (hazard ratio [95% confidence interval] 1.14 [0.70, 1.86], p trend = .59).
conclusionsHigher protein intake was beneficially associated with maintenance of physical function in middle-aged, high-functioning U.S. adults over the span of two decades. This association was particularly evident in women.
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