ArticleTransplantation2019
Early Hypertension and Diabetes After Living Kidney Donation: A National Cohort Study.
Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Pooled it
- Obesity in Living Kidney Donors from Risk to Ethics: Bridging Gaps in Evaluation and Management.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026Review
- Landscape of current practices and future perspectives in living donor kidney donation in Europe: proceedings of a pan-European symposium by the European kidney transplant association section of the European Society for Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Renal function outcomes in living kidney donors in a transplant center in Colombia.SAGE open medicine · 2024Article
- External Validation of Toulouse-Rangueil eGFR12 Prediction Model After Living Donor Nephrectomy.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- The Living Kidney Donor Safety Study: Protocol of a Prospective Cohort Study.Canadian journal of kidney health and disease · 2022Article
- Practice Patterns in the Acceptance of Medically Complex Living Kidney Donors with Obesity, Hypertension, Family History of Kidney Disease, or Donor-Recipient Age Discrepancy.Avicenna journal of medicine · 2021Article
- One size does not fit all: understanding individual living kidney donor risk.Pediatric nephrology (Berlin, Germany) · 2021Review
- Prevalence, Mechanisms, Treatment, and Complications of Hypertension Postliving Kidney Donation.BioMed research international · 2021Review
- Association Between Living Kidney Donor Postdonation Hypertension and Recipient Graft Failure.Transplantation · 2020Article
- Postdonation eGFR and New-Onset Antihypertensive Medication Use After Living Kidney Donation.Transplantation direct · 2019Article
- JCV viruria associates with suboptimal recovery of kidney function three years after living kidney donation.Jornal brasileiro de nefrologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundLiving kidney donors have an increased risk of end-stage renal disease, with hypertension and diabetes as the predominant causes. In this study, we sought to better understand the timeline when these diseases occur, focusing on the early postdonation period.
methodsWe studied 41 260 living kidney donors in the United States between 2008 and 2014 from the Scientific Registry of Transplant Recipients and modeled incidence rates and risk factors for hypertension and diabetes.
resultsAt 6 months, 1 year, and 2 years postdonation, there were 74, 162, and 310 cases, respectively, of hypertension per 10 000 donors. Donors who were older (per 10 y, adjusted incidence rate ratio [aIRR], 1.40; 95% confidence interval [CI], 1.29-1.51), male (aIRR, 1.31; 95% CI, 1.14-1.50), had higher body mass index (per 5 units, aIRR, 1.29; 95% CI, 1.17-1.43), and were related to their recipient (first-degree relative: aIRR, 1.28; 95% CI, 1.08-1.52; spouse: aIRR, 1.34; 95% CI, 1.08-1.66) were more likely to develop hypertension, whereas donors who were Hispanic/Latino were less likely (aIRR, 0.71; 95% CI, 0.55-0.93). At 6 months, 1 year, and 2 years, there were 2, 6, and 15 cases of diabetes per 10 000 donors. Donors who were older (per 10 y: aIRR, 1.42; 95% CI, 1.11-1.82), had higher body mass index (per 5 units: aIRR, 1.52; 95% CI, 1.04-2.21), and were Hispanic/Latino (aIRR, 2.45; 95% CI, 1.14-5.26) were more likely to develop diabetes.
conclusionsIn this national study, new-onset diabetes was rare, but 3% of donors developed hypertension within 2 years of nephrectomy. These findings reaffirm that disease pathways for kidney failure differ by donor phenotype and estimate the population most at-risk for later kidney failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.