Evidence map›Paper›PMID 30247091›Full record

ArticleThe New England journal of medicine2018

Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury.

Claudia A Angeli, Maxwell Boakye, Rebekah A Morton, Justin Vogt, Kristin Benton, Yangshen Chen, Christie K Ferreira, Susan J Harkema

8 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 367 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02339233 nacompletednot on this map

Spinal Epidural Electrode Array to Facilitate Standing and Stepping After Spinal Cord Injury

TypeinterventionalSponsorUniversity of LouisvilleRan2010 to 2019Enrolled8ConditionsSpinal Cord InjuryArmsStanding and Stepping with spinal cord Epidural Stimulation
NCT04807764 nacompletednot on this mapstarted 2021, after this paper: background citation

Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2021 to 2024Enrolled14ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsStanding transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training
NCT04965727 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury

TypeinterventionalSponsorJocelyne BlochRan2021 to 2026Enrolled3ConditionsDeep Brain Stimulation, Neuro: Spinal Cord InjuryArmsDevice implantation
NCT05926843 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury: an Interventional, Prospective, Monocentric Study

TypeinterventionalSponsorIRCCS San RaffaeleRan2023 to 2026Enrolled10ConditionsSpinal Cord InjuriesArmsSpinal cord stimulation surgery (device) and motor rehabilitation
NCT05966896 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury: Spared Fibers Proof-of-concept Study

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2027Enrolled2ConditionsSpinal Cord InjuriesArmsimplanted epidural stimulator
NCT06213012 narecruitingnot on this mapstarted 2023, after this paper: background citation

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

TypeinterventionalSponsorThe Methodist Hospital Research InstituteRan2023 to 2027Enrolled60ConditionsSpinal Cord Injuries, NeuromodulationArmsTranscutaneous Spinal cord Stimulation, Epidural Spinal Stimulation (ESS)
NCT07375745 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI

TypeinterventionalSponsorCentre for Interdisciplinary Research in Rehabilitation of Greater MontrealRan2026 to 2029Enrolled40ConditionsSpinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, SensorimotorArmsProtocol 1: Gait training combined with a sham stimulation, Protocol 2: Gait training combined with an effective tSCS
NCT07412808 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function in Non-traumatic Spinal Cord Injury: an Interventional, Prospective, Monocentric Study

TypeinterventionalSponsorAlbano LuigiRan2026 to 2029Enrolled10ConditionsSpinal Cord Disease, Spinal Cord Injuries (Complete and Incomplete)ArmsSpinal cord stimulation surgery (device implant) and motor rehabilitation
3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  15. In conversation with Grégoire Courtine.Nature neuroscience · 2026
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307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Claudia A AngeliFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Maxwell BoakyeFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Rebekah A MortonFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Justin VogtFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Kristin BentonFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Yangshen ChenFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Christie K FerreiraFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
Susan J HarkemaFrom the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention of some sensation, do not recover independent walking. We tested intense locomotor treadmill training with weight support and simultaneous spinal cord epidural stimulation in four patients 2.5 to 3.3 years after traumatic spinal injury and after failure to improve with locomotor training alone. Two patients, one with damage to the mid-cervical region and one with damage to the high-thoracic region, achieved over-ground walking (not on a treadmill) after 278 sessions of epidural stimulation and gait training over a period of 85 weeks and 81 sessions over a period of 15 weeks, respectively, and all four achieved independent standing and trunk stability. One patient had a hip fracture during training. (Funded by the Leona M. and Harry B. Helmsley Charitable Trust and others; ClinicalTrials.gov number, NCT02339233 .).

Indexed as

Exercise TherapyRecovery of FunctionSpinal Cord StimulationWalkingAdultChronic DiseaseElectrodes, ImplantedEpidural SpaceHumansLocomotionMaleSpinal Cord Injuries

Identifiers

PMID30247091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.