ArticleJournal of neural engineering2018
Long-term recording reliability of liquid crystal polymer µECoG arrays.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Temporally Delayed Deployment of Photo-Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces.Advanced healthcare materials · 2026Article
- Reliability of ultra-thin metal films integrated onto embossed and bonded liquid-crystal-polymer (LCP) sheets for neural-interface applications.Frontiers in neuroscience · 2026Article
- Long-Term Stable Subdural Recordings Enabled by Fibrosis-Resistant Hydrogel-Integrated µECoG Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Distinct cortical encoding of acoustic and electrical cochlear stimulation.bioRxiv : the preprint server for biology · 2025Article
- Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.Nature biomedical engineering · 2025Review
- Intan Technologies integrated circuits can produce analog-to-digital conversion artifacts that affect neural signal acquisition.Journal of neural engineering · 2024Article
- The speech neuroprosthesis.Nature reviews. Neuroscience · 2024Review
- Motor Behavior Regulation of Rat Robots Using Integrated Electrodes Stimulated by Micro-Nervous System.Micromachines · 2024Article
- High-density cortical µECoG arrays concurrently track spreading depolarizations and long-term evolution of stroke in awake rats.Communications biology · 2024Article
- Article
- High-resolution neural recordings improve the accuracy of speech decoding.Nature communications · 2023Article
- Fully desktop fabricated flexible graphene electrocorticography (ECoG) arrays.Journal of neural engineering · 2023Article
- Flexural bending to approximate cortical forces exerted by electrocorticography (ECoG) arrays.Journal of neural engineering · 2022Article
- A Fully Implantable Miniaturized Liquid Crystal Polymer (LCP)-Based Spinal Cord Stimulator for Pain Control.Sensors (Basel, Switzerland) · 2022Article
- High-Density, Actively Multiplexed μECoG Array on Reinforced Silicone Substrate.Frontiers in nanotechnology · 2022Article
- Flexible, high-resolution thin-film electrodes for human and animal neural research.Journal of neural engineering · 2021Article
- Evaluation methods for long-term reliability of polymer-based implantable biomedical devices.Biomedical engineering letters · 2021Review
- Sufficient sampling for kriging prediction of cortical potential in rat, monkey, and human µECoG.Journal of neural engineering · 2021Article
- Cortical mapping of mismatch responses to independent acoustic features.Hearing research · 2021Article
- Versatile Surface Electrodes for Combined Electrophysiology and Two-Photon Imaging of the Mouse Central Nervous System.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces. APPROACH: We evaluated the chronic reliability of novel 61-channel micro-electrocorticographic (µECoG) arrays in rats chronically implanted for over one year and using accelerated aging. Devices were encapsulated with polyimide (PI) or liquid crystal polymer (LCP), and fabricated using commercial manufacturing processes. In vitro failure modes and predicted lifetimes were determined from accelerated soak testing. Successful designs were implanted epidurally over the rodent auditory cortex. Trends in baseline signal level, evoked responses and decoding performance were reported for over one year of implantation. MAIN
resultsDevices fabricated with LCP consistently had longer in vitro lifetimes than PI encapsulation. Our accelerated aging results predicted device integrity beyond 3.4 years. Five implanted arrays showed stable performance over the entire implantation period (247-435 d). Our regression analysis showed that impedance predicted signal quality and information content only in the first 31 d of recordings and had little predictive value in the chronic phase (>31 d). In the chronic phase, site impedances slightly decreased yet decoding performance became statistically uncorrelated with impedance. We also employed an improved statistical model of spatial variation to measure sensitivity to locally varying fields, which is typically concealed in standard signal power calculations. SIGNIFICANCE: These findings show that µECoG arrays can reliably perform in chronic applications in vivo for over one year, which facilitates the development of a high-density, clinically viable interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.