ArticleJournal of psychiatry & neuroscience : JPN2019
Cerebral blood flow in striatal regions is associated with apathy in patients with schizophrenia.
Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The hippocampal-cortical system cerebral blood flow in schizophrenia: Primary disease versus antipsychotic medication effects.Schizophrenia research · 2026Article
- A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.Noro psikiyatri arsivi · 2025Review
- Illness-related variables and abnormalities of resting-state brain activity in schizophrenia.Frontiers in psychiatry · 2024Article
- Resting-state perfusion in motor and fronto-limbic areas is linked to diminished expression of emotion and speech in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.Schizophrenia (Heidelberg, Germany) · 2023Article
- Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response.Psychological medicine · 2023Article
- Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study.Brain sciences · 2023Article
- Regional cortical perfusion increases induced by a 6-month endurance training in young sedentary adults.Frontiers in aging neuroscience · 2022Article
- Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations.Human brain mapping · 2020Article
- Decreased Relative Cerebral Blood Flow in Unmedicated Heroin-Dependent Individuals.Frontiers in psychiatry · 2020Article
- Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness.Experimental aging researchArticle
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9 authors.
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Abstract
backgroundStriatal dysfunction has been proposed as a pathomechanism for negative symptoms in schizophrenia. There is consensus that negative symptoms can be grouped into 2 dimensions: apathy and diminished expression. Recent studies suggest that different neural mechanisms underlie these dimensions, but the relationship between regional resting-state cerebral blood flow (rCBF) and negative symptom dimensions has not been investigated.
methodsThis study included 29 patients with schizophrenia and 20 healthy controls. We measured rCBF in the striatum using arterial spin labelling (ASL) MRI. We assessed negative symptoms using the Brief Negative Symptom Scale.
resultsIn the ventral and dorsal striatum, rCBF was not different between patients with schizophrenia and controls. However, we did find a positive association between the severity of apathy and increased rCBF in the ventral and dorsal striatum in patients with schizophrenia. This effect was not present for diminished expression. LIMITATIONS: All patients were taking atypical antipsychotics, so an effect of antipsychotic medication on rCBF could not be excluded, although we did not find a significant association between rCBF and chlorpromazine equivalents.
conclusionThe main finding of this study was a specific association between increased striatal rCBF and the negative symptom dimension of apathy. Our results further support the separate assessment of apathy and diminished expression when investigating the neural basis of negative symptoms. The ASL technique can provide a direct and quantitative approach to investigating the role of rCBF changes in the pathophysiology of negative symptoms.
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