Evidence map›Paper›PMID 30246479›Full record

ArticleJournal of cellular biochemistry2019

TIEG1 is upregulated in Lrp5/6-mediated valve osteogenesis.

Nalini M Rajamannan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nalini M RajamannanDepartment of Cardiology, Most Sacred Heart of Jesus Cardiology and Valvular Institute, Sheboygan, Wisconsin.ORCID 0000-0002-3671-0464
Mayo Clinic · US

Funding

Role of Lrp5/Beta-Catenin in Aortic Valve CalcificationR01HL085591 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAJAMANNAN, NALINI M · 2007 to 2011
$2.1M
NHLBI NIH HHS R01 HL085591
6 · The paper itself

Abstract

We have previously demonstrated that Lrp5/6/β-catenin plays an important role in valve calcification with a specific osteogenic phenotype defined by increased bone mineral content and overall valve thickening. Recent studies indicate that TIEG1 may be involved in mediating the Wnt signaling pathway in bone, which is known to play critical roles in osteoblast differentiation and bone mineralization. Therefore, we sought to test the role of TIEG1 in mediating Wnt signaling, in an established model of hypercholesterolemic valve disease. Our previous model treated null mice with cholesterol diets: Lrp5

Indexed as

OsteogenesisAnimalsAortic Valve StenosisCalcinosisCell DifferentiationCore Binding Factor Alpha 1 SubunitDNA-Binding ProteinsEarly Growth Response Transcription FactorsFemaleHypercholesterolemiaKruppel-Like Transcription FactorsLow Density Lipoprotein Receptor-Related Protein-5Low Density Lipoprotein Receptor-Related Protein-6MaleMiceMice, KnockoutCore Binding Factor Alpha 1 SubunitDNA-Binding ProteinsEarly Growth Response Transcription FactorsKLF10 protein, mouseKruppel-Like Transcription FactorsLow Density Lipoprotein Receptor-Related Protein-5Low Density Lipoprotein Receptor-Related Protein-6Lrp5 protein, mouseLrp6 protein, mouseRunx2 protein, mouseTranscription FactorslipidsLrp5osteoblastogenesisTIEG1

Identifiers

PMID30246479
PMCPMC6336497
OpenAlexW2894542877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.