ArticleEvolution; international journal of organic evolution2018
Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes.
Article in Evolution; international journal of organic evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans.Heredity · 2025Article
- Article
- Effect of MHC and inbreeding on disassortative reproduction: A data revisit, extension and inclusion of fertilization in sand lizards.Ecology and evolution · 2023Article
- Cryptic female choice within individual males - A neglected component of the postmating sexual selection?Journal of evolutionary biology · 2022Review
- A Review of Suggested Mechanisms of MHC Odor Signaling.Biology · 2022Review
- Article
- Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.International journal of molecular sciences · 2022Article
- Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility.Human reproduction (Oxford, England) · 2021Article
- Within-trio tests provide little support for post-copulatory selection on major histocompatibility complex haplotypes in a free-living population.Proceedings. Biological sciences · 2021Article
- Host-parasite co-evolution and its genomic signature.Nature reviews. Genetics · 2020Review
- Gamete-level immunogenetic incompatibility in humans-towards deeper understanding of fertilization and infertility?Heredity · 2020Article
- Deciphering genetic mate choice: Not so simple in group-housed conservation breeding programs.Evolutionary applications · 2020Article
- Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function.Proceedings. Biological sciences · 2020Article
- Rare polyandry and common monogamy in the firefly squid, Watasenia scintillans.Scientific reports · 2020Article
- Article
- Sperm success and immunity.Current topics in developmental biology · 2019Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Females choose specific mates in order to produce fitter offspring. However, several factors interfere with females' control over fertilization of their eggs, including sneaker males and phenotypically unpredictable allele segregation during meiosis. Mate choice at the individual level thus provides only a poor approximation for obtaining the best genetic match. Consequently, postcopulatory sperm selection by female oocytes has been proposed as a mechanism to achieve complementary combinations of parental haplotypes. Here, using controlled in vitro fertilization of three-spined stickleback eggs, we find haplotype-specific fertilization bias toward gametes with complementary major histocompatibility complex (MHC) immunogenes. The resulting zygote (and thus offspring) genotypes exhibit an intermediate level of individual MHC diversity that was previously shown to confer highest pathogen resistance. Our finding of haplotype-specific gamete selection thus represents an intriguing mechanism for fine-tuned optimization of the offspring's immune gene composition and an evolutionary advantage in the Red Queen dynamics of host-parasite coevolution.
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