ArticleMagnetic resonance in medicine2019
Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 100 citations in OpenAlex.
- Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.Magnetic resonance in medicine · 2026Article
- High-Temporal-Resolution Monitoring of Creatine and Phosphocreatine Dynamics in Skeletal Muscle Using Ultrafast Z-Spectroscopy (UFZ) CEST MRI at 3T.Magnetic resonance in medicine · 2026Article
- Self-Derived Dynamic Field Map Estimation and Correction in CEST MRI.Magnetic resonance in medicine · 2026Article
- Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global-Local Two-Branch Deep Learning Model.Magnetic resonance in medicine · 2026Article
- Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle.NMR in biomedicine · 2026Article
- Article
- A Novel CEST-Based Approach for Reliably Assessing Skeletal Muscle Oxidative Phosphorylation: OXCEST.Magnetic resonance in medicine · 2026Article
- A rapid and accurate guanidine CEST imaging in ischemic stroke using a machine learning approach.Physics in medicine and biology · 2026Article
- Inverting CEST orMagnetic resonance in medicine · 2026Article
- Chemical exchange saturation transfer MRI for neurodegenerative diseases: An update on clinical and preclinical studies.Neural regeneration research · 2026Article
- Evaluating the effectiveness of distortion self-correction for CEST-EPI.Magnetic resonance in medicine · 2026Article
- CEST MRI data analysis using Kolmogorov-Arnold network (KAN) and Lorentzian-KAN (LKAN) models.Magnetic resonance in medicine · 2025Article
- Double-Step R1rho-Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods.NMR in biomedicine · 2025Article
- CESTsimu: An open-source GUI for spectral and spatial CEST simulation.Magnetic resonance in medicine · 2025Article
- Simultaneous monitoring of glycogen, creatine, and phosphocreatine in type II glycogen storage disease using saturation transfer MRI.Magnetic resonance in medicine · 2025Article
- Ungated, plug-and-play preclinical cardiac CEST-MRI using radial FLASH with segmented saturation.Magnetic resonance in medicine · 2025Article
- Toward quantitative CEST imaging of glutamate in the mouse brain using a multi-pool exchange model calibrated byMagnetic resonance in medicine · 2025Article
- Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T.Magnetic resonance in medicine · 2025Article
- MRI of GlycoNOE in the human liver using GraspNOE-Dixon.Magnetic resonance in medicine · 2025Article
- Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm.Quantitative imaging in medicine and surgery · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo obtain high-resolution Cr and PCr maps of mouse skeletal muscle using a polynomial and Lorentzian line-shape fitting (PLOF) CEST method.
methodsWild-type mice and guanidinoacetate N-methyltransferase-deficient (GAMT-/-) mice that have low Cr and PCr concentrations in muscle were used to assign the Cr and PCr peaks in the Z-spectrum at 11.7 T. A PLOF method was proposed to simultaneously extract and quantify the Cr and PCr by assuming a polynomial function for the background and 2 Lorentzian functions for the CEST peaks at 1.95 ppm and 2.5 ppm.
resultsThe Z-spectra of phantoms revealed that PCr has 2 CEST peaks (2 ppm and 2.5 ppm), whereas Cr only showed 1 peak at 2 ppm. Comparison of the Z-spectra of wild-type and GAMT-/- mice indicated that, contrary to brain, there was no visible protein guanidinium peak in the skeletal-muscle Z-spectrum, which allowed us to extract clean PCr and Cr CEST signals. High-resolution PCr and Cr concentration maps of mouse skeletal muscle were obtained by the PLOF CEST method after calibration with in vivo MRS.
conclusionsThe PLOF method provides an efficient way to map Cr and PCr concentrations simultaneously in the skeletal muscle at high MRI field.
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