ArticleBrain and neuroscience advances2017
Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination.
Article in Brain and neuroscience advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Distinct cortical spatial representations learned along disparate visual pathways.Science advances · 2026Article
- The Contribution of Spatially Tuned Brain Cells to Human Navigation Performance.KN - journal of cartography and geographic information · 2026Review
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition.Molecular psychiatry · 2025Article
- Phase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells.Hippocampus · 2025Article
- A systems model of alternating theta sweeps via firing rate adaptation.Current biology : CB · 2025Article
- Unweaving the Cognitive Map: A Personal History.Hippocampus · 2025Review
- Comparison of head direction cell firing characteristics across thalamo-parahippocampal circuitry.Hippocampus · 2024Article
- Mapping brain networks in MPS I mice and their restoration following gene therapy.Scientific reports · 2023Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- Convergence of location, direction, and theta in the rat anteroventral thalamic nucleus.iScience · 2023Article
- Learning the Vector Coding of Egocentric Boundary Cells from Visual Data.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions.Nature communications · 2023Article
- Coregistration of heading to visual cues in retrosplenial cortex.Nature communications · 2023Article
- Symmetries and asymmetries in the neural encoding of 3D space.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Review
- Retrosplenial and subicular inputs converge on superficially projecting layer V neurons of medial entorhinal cortex.Brain structure & function · 2022Article
- Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals.Nature communications · 2022Article
- Angular and linear speed cells in the parahippocampal circuits.Nature communications · 2022Article
- Moving bar of light evokes vectorial spatial selectivity in the immobile rat hippocampus.Nature · 2022Article
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6 authors.
Funding
Abstract
backgroundVisual landmarks are used by head direction (HD) cells to establish and help update the animal's representation of head direction, for use in orientation and navigation. Two cortical regions that are connected to primary visual areas, postsubiculum (PoS) and retrosplenial cortex (RSC), possess HD cells: we investigated whether they differ in how they process visual landmarks.
methodsWe compared PoS and RSC HD cell activity from tetrode-implanted rats exploring an arena in which correct HD orientation required discrimination of two opposing landmarks having high, moderate or low discriminability.
resultsRSC HD cells had higher firing rates than PoS HD cells and slightly lower modulation by angular head velocity, and anticipated actual head direction by ~48 ms, indicating that RSC spiking leads PoS spiking. Otherwise, we saw no differences in landmark processing, in that HD cells in both regions showed equal responsiveness to and discrimination of the cues, with cells in both regions having unipolar directional tuning curves and showing better discrimination of the highly discriminable cues. There was a small spatial component to the signal in some cells, consistent with their role in interacting with the place cell navigation system, and there was also slight modulation by running speed. Neither region showed theta modulation of HD cell spiking.
conclusionsThat the cells can immediately respond to subtle differences in spatial landmarks is consistent with rapid processing of visual snapshots or scenes; similarities in PoS and RSC responding may be due either to similar computations being performed on the visual inputs, or to rapid sharing of information between these regions. More generally, this two-cue HD cell paradigm may be a useful method for testing rapid spontaneous visual discrimination capabilities in other experimental settings.
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