ArticleBone reports2018
Ptychographic X-ray CT characterization of the osteocyte lacuno-canalicular network in a male rat's glucocorticoid induced osteoporosis model.
Article in Bone reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Ptychographic reconstructions performed in real time and offline have equivalent quality.Scientific reports · 2025Article
- The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis.JCI insight · 2024Article
- A novel tape-free sample preparation method for human osteochondral cryosections for high throughput hyperspectral imaging.Histochemistry and cell biology · 2024Article
- The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice.Calcified tissue international · 2024Article
- Characterization of human trabecular bone across multiple length scales using a correlative approach combining X-ray tomography with LaserFIB and plasma FIB-SEM.Scientific reports · 2024Article
- Crossing length scales: X-ray approaches to studying the structure of biological materials.IUCrJ · 2024Review
- 2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS).Current osteoporosis reports · 2024Review
- The osteocytic actions of glucocorticoids on bone mass, mechanical properties, or perilacunar remodeling outcomes are not rescued by PTH(1-34).Frontiers in endocrinology · 2024Article
- Influence of Osteocyte Lacunar-Canalicular Morphology and Network Architecture on Osteocyte Mechanosensitivity.Current osteoporosis reports · 2023Review
- A technique for preparing undecalcified osteochondral fresh frozen sections for elemental mapping and understanding disease etiology.Histochemistry and cell biology · 2022Article
- Evaluation of imaging setups for quantitative phase contrast nanoCT of mineralized biomaterials.Journal of synchrotron radiation · 2022Article
- High-speed free-run ptychography at the Australian Synchrotron.Journal of synchrotron radiation · 2022Article
- Review
- TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Advancements in composition and structural characterization of bone to inform mechanical outcomes and modelling.Current opinion in biomedical engineering · 2019Article
- Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone.Current osteoporosis reports · 2019Review
- Investigating Osteocytic Perilacunar/Canalicular Remodeling.Current osteoporosis reports · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ptychographic X-ray computed tomography (PXCT) is a quantitative imaging modality that non-destructively maps the 3D electron density inside an object with tens of nanometers spatial resolution. This method provides unique access to the morphology and structure of the osteocyte lacuno-canalicular network (LCN) and nanoscale density of the tissue in the vicinity of an osteocyte lacuna. Herein, we applied PXCT to characterize the lacunae and LCN in a male Wistar rat model of glucocorticoid-induced osteoporosis (GIO). The ptychographic images revealed significant (p < 0.05) differences in the number of canaliculi originating from the lacuna per ellipsoidal surface unit, Ca.Nb (p = 0.0106), and the 3D morphology of the lacuna (p = 0.0064), between GIO and SHAM groups. Moreover, the mean canalicular diameter, Ca.Dm, was slightly statistically un-significantly smaller in GIO (152 ± 6.5) nm than in SHAM group (165 ± 8) nm (p = 0.053). Our findings indicate that PXCT can non-destructively provide detailed, nanoscale information on the 3D organization of the LCN in correlative studies of pathologies, such as osteoporosis, leading to improved diagnosis and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.