Evidence map›Paper›PMID 30246025›Full record

ArticleBioMed research international2018

Serum Stem Cell Growth Factor Beta for the Prediction of Therapy Response in Hepatocellular Carcinoma.

Caecilia H C Sukowati, Riccardo Patti, Devis Pascut, Rusdina B Ladju, Paola Tarchi, Nunzia Zanotta, Manola Comar, Claudio Tiribelli, Lory S Crocè

Abstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caecilia H C SukowatiFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.ORCID 0000-0001-9699-7578
Riccardo PattiFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.
Devis PascutFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.
Rusdina B LadjuFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.
Paola TarchiTeaching Hospital, ASUITS, Trieste, Italy.
Nunzia ZanottaInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Manola ComarDepartment of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy.
Claudio TiribelliFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.
Lory S CrocèFondazione Italiana Fegato, AREA Science Park Basovizza, Trieste, Italy.ORCID 0000-0001-9890-7011

Funding

MIF in progression and treatment of ALDU01AA020821 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2016
$2.1M
NIAAA NIH HHS U01 AA020821
6 · The paper itself

Abstract

introductionChronic inflammatory response is one of major contributors in the development of hepatocellular carcinoma (HCC). Inflammatory molecules, such as cytokines and growth factors in the circulation, can be useful in the diagnosis and prognosis of the patients. The stem cell growth factor beta (SCGF

methodsA multiplex immunoassay panel of 48 cytokines and growth factors were utilized to screen 68 sera from 29 HCC patients at pretreatment (T0), 1 month (T1), and 6 months (T6) after treatment by either radiofrequency ablation (RF) or transarterial chemoembolization (TACE). Treatment response was evaluated according to mRECIST criteria.

resultsImmunoassay screening showed that the levels of IL-17, CTACK, TNF

conclusionIn this study, for the first time, we demonstrate that the high level of serum SCGF

Indexed as

AgedCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHematopoietic Cell Growth FactorsHumansLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesStem CellsTreatment OutcomeHematopoietic Cell Growth Factors

Identifiers

PMID30246025
PMCPMC6136561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.