Evidence map›Paper›PMID 30245994›Full record

ArticleRevista brasileira de ortopedia

Evaluation of different commercial hyaluronic acids as a vehicle for injection of human adipose-derived mesenchymal stem cells.

Camila Cohen Kaleka, Eder Zucconi, Tierri da Silva Vieira, Mariane Secco, Mário Ferretti, Moisés Cohen

Abstract read
In one paragraph

Article in Revista brasileira de ortopedia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Treatment of Muscle Injury with Stem Cells -Revista brasileira de ortopedia · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camila Cohen KalekaInstituto Cohen Ortopedia, Reabilitação e Medicina do Esporte, São Paulo, SP, Brazil.
Eder ZucconiDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Tierri da Silva VieiraInstituto Cohen Ortopedia, Reabilitação e Medicina do Esporte, São Paulo, SP, Brazil.
Mariane SeccoDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Mário FerrettiPrograma do Aparelho Locomotor, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Moisés CohenInstituto Cohen Ortopedia, Reabilitação e Medicina do Esporte, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe main purpose of this study is to evaluate,

methodsAD-MSCs were divided into seven groups: one control group where AD-MSCs were cultivated with phosphate-buffered saline (PBS) and six other groups where AD-MSCs were cultivated with different commercial brands of hyaluronic acid. AD-MSC viability analysis was performed after 4, 24, and 48 h in contact with each treatment, using the trypan staining method on a Countess automated cell counter (Thermo Fisher Scientific).

resultsThe results clearly demonstrated a significant difference in cell viability when AD-MSCs were exposed to different hyaluronic acids when compared with the control group.

conclusionThese data suggest that hyaluronic acid can be used as a vehicle for injection of human AD-MSCs, but caution is needed to choose the best product, aiming at its future therapeutic application.

Indexed as

ArthroscopyArticular cartilageCartilage diseasesKneeMesenchymal stem cellsMesenchymal stem cell transplantation

Identifiers

PMID30245994
PMCPMC6147760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.