Evidence map›Paper›PMID 30245966›Full record

ArticleActa pharmaceutica Sinica. B2018

Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1

Keke Wang, Ranran Ding, Yanping Ha, Yanan Jia, Xiaomin Liao, Sisi Wang, Rujia Li, Zhihua Shen, Hui Xiong, Junli Guo and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026
    Review
  2. Article
  3. Article
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  5. Review
  6. Article
  7. Review
  8. Article
  9. New Insights into the Reparative Angiogenesis after Myocardial Infarction.International journal of molecular sciences · 2023
    Review
  10. Notch signaling, hypoxia, and cancer.Frontiers in oncology · 2023
    Review
  11. Disruption of adipocyte HIF-1Acta pharmaceutica Sinica. B · 2022
    Article
  12. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. The Effects of Inhibition of MicroRNA-375 in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  19. MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Keke WangDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Ranran DingDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Yanping HaDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Yanan JiaDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Xiaomin LiaoDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Sisi WangDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Rujia LiDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Zhihua ShenDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Hui XiongDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Junli GuoCardiovascular Institute of First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Wei JieDepartment of Pathology, Guangdong Medical University, Zhanjiang 52 4023, China.
Guangdong Medical College · CNHainan Medical University · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury, but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes (CMs) for driving the differentiation of cardiac stem cells (CSCs). Forced hypoxia-inducible factor 1

Indexed as

BMSCs, bone marrow stem cellsBrdU, 5-bromo-2′-deoxyuridineCardiac stem cellCardiomyocyte, Co-cultureCell differentiationCMs, cardiomyocytesCSCs, cardiac stem cellsDAPI, 4′,6-diamidino-2-phenylindoleDMSO, dimethyl sulfoxideERK, extracellular signal-regulated kinaseFBS, fetal bovine serumFITC, fluorescein isothiocyanateGFP, green fluorescent proteinHIF-1α, hypoxia-inducible factor 1αHRE, hypoxia responsive elementHypoxiaJAK, Janus kinaseJNK, c-Jun N-terminal kinaseMACS, magnetic-activated cell sortingMI, myocardial infarctionMOI, multiplicity of infectionNF-κB, nuclear factor κBN-ICD, notch intracellular domainNotch1 signalingPBS, phosphate buffer salinePE, phycoerythrinqPCR, quantitative PCRRT-PCR, reverse transcription PCRSTAT3, signal transducer and activator of transcription 3vWF, von Willebrand factorYC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl-indazole

Identifiers

PMID30245966
PMCPMC6148082
OpenAlexW2808649851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.