Evidence map›Paper›PMID 30245736›Full record

ArticleBiomedical signal processing and control2018

A quantitative performance study of two automatic methods for the diagnosis of ovarian cancer.

Manuel A Vázquez, Inés P Mariño, Oleg Blyuss, Andy Ryan, Aleksandra Gentry-Maharaj, Jatinderpal Kalsi, Ranjit Manchanda, Ian Jacobs, Usha Menon, Alexey Zaikin

Abstract read
In one paragraph

Article in Biomedical signal processing and control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manuel A VázquezDepartment of Signal Theory and Communications, Universidad Carlos III de Madrid, Leganés 28911, Madrid, Spain.
Inés P MariñoDepartment of Biology and Geology, Physics and Inorganic Chemistry, Universidad Rey Juan Carlos, Móstoles 28933, Madrid, Spain.
Oleg BlyussCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
Andy RyanDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Aleksandra Gentry-MaharajDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Jatinderpal KalsiDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Ranjit ManchandaDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Ian JacobsDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Usha MenonDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.
Alexey ZaikinDepartment of Women's Cancer, Institute for Women's Health, University College London, London WC1E 6BT, United Kingdom.

Funding

Cancer Research UK 12677Medical Research Council G9901012
6 · The paper itself

Abstract

We present a quantitative study of the performance of two automatic methods for the early detection of ovarian cancer that can exploit longitudinal measurements of multiple biomarkers. The study is carried out for a subset of the data collected in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). We use statistical analysis techniques, such as the area under the Receiver Operating Characteristic (ROC) curve, for evaluating the performance of two techniques that aim at the classification of subjects as either healthy or suffering from the disease using time-series of multiple biomarkers as inputs. The first method relies on a Bayesian hierarchical model that establishes connections within a set of clinically interpretable parameters. The second technique is a purely discriminative method that employs a recurrent neural network (RNN) for the binary classification of the inputs. For the available dataset, the performance of the two detection schemes is similar (the area under ROC curve is 0.98 for the combination of three biomarkers) and the Bayesian approach has the advantage that its outputs (parameters estimates and their uncertainty) can be further analysed by a clinical expert.

Indexed as

Bayesian estimationBiomarkersChange-point detectionDeep learningGibbs samplingMarkov chainMonte CarloOvarian cancerRecurrent neural networks

Identifiers

PMID30245736
PMCPMC6146655

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.