ArticleGastroenterology research and practice2018
Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study.
Article in Gastroenterology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Effect of Race and Tumor Subsite on Survival Outcome in Early- and Late-Onset Colorectal Cancer.Cancers · 2026Article
- The Role of Tumor Location on Endoscopic and Surgical Management of Malignant Colon Polyps.Annals of surgical oncology · 2024Article
- American Indian/Alaska Native and black colon cancer patients have poorer cause-specific survival based on disease stage and anatomic site of diagnosis.Cancer epidemiology · 2022Article
- Risk of colon cancer-related death in people who had cancer in the past.International journal of colorectal disease · 2022Article
- The Bioinformatics-Based Analysis Identifies 7 Immune-Related Genes as Prognostic Biomarkers for Colon Cancer.Frontiers in oncology · 2021Article
- Better survival of right-sided than left-sided stage II colon cancer: a propensity scores matching analysis based on SEER database.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Effect ofOncology letters · 2020Article
- The Impact of Primary Tumor Location in Synchronous Metastatic Colorectal Cancer: Differences in Metastatic Sites and Survival.Annals of surgical oncology · 2020Article
- Predictive Risk Factors and Online Nomograms for Synchronous Colon Cancer With Liver Metastasis.Frontiers in oncology · 2020Article
- Tumor sidedness influences prognostic impact of lymph node metastasis in colon cancer patients undergoing curative surgery.Scientific reports · 2019Article
- Right-sided vs. left-sided obstructing colonic cancer: results of a multicenter study of the French Surgical Association in 2325 patients and literature review.International journal of colorectal disease · 2019Review
- The rise of proximal colorectal cancer: a trend analysis of subsite specific primary colorectal cancer in the SEER database.Annals of gastroenterologyArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn terms of incidence and pathogenesis, right-sided colon cancer (RCC) and left-sided colon cancer (LCC) exhibit several differences. However, whether existing differences could reflect the different survival outcomes remains unclear. Therefore, we aimed to ascertain the role of location in the prognosis.
methodsWe identified colon cancer cases from the Surveillance, Epidemiology, and End Results database between 1973 and 2012. Differences among subsites of colon cancer regarding clinical features and metastatic patterns were compared. The Kaplan-Meier curves were conducted to compare overall and disease-specific survival in relation to cancer location. The effect of tumour location on overall and cancer-specific survival was analysed by Cox proportional hazards model.
resultsA total of 377,849 patients from SEER database were included in the current study, with 180,889 (47.9%) RCC and 196,960 (52.1%) LCC. LCC was more likely to metastasize to the liver and lung. Kaplan-Meier curves demonstrated that LCC patients had better overall and cancer-specific survival outcomes. Among Cox multivariate analyses, LCC was associated with a slightly reduced risk of overall survival (HR, 0.92; 95% CI, 0.92-0.93) and cancer-specific survival (HR, 0.92; 95% CI, 0.91-0.93), even after adjusted for other variables. However, the relationship between location and prognosis was varied by subgroups defined by age, year at diagnosis, stage, and therapies.
conclusionsWe demonstrated that LCC was associated with better prognosis, especially for patients with distant metastasis. Future trails should seek to identify the underlying mechanism.
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