Evidence map›Paper›PMID 30245672›Full record

ArticleFrontiers in microbiology2018

Blood or Serum Exposure Induce Global Transcriptional Changes, Altered Antigenic Profile, and Increased Cytotoxicity by Classical Bordetellae.

Monica C Gestal, Israel Rivera, Laura K Howard, Kalyan K Dewan, Illiassou Hamidou Soumana, Margaret Dedloff, Tracy L Nicholson, Bodo Linz, Eric T Harvill

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Frontiers in cellular and infection microbiology · 2023
    Article
  7. Article
  8. Conquering the host:Frontiers in microbiology · 2022
    Review
  9. Omics Analysis of Blood-Responsive Regulon inInternational journal of molecular sciences · 2021
    Article
  10. Review
  11. DisruptingMicroorganisms · 2020
    Article
  12. Article
  13. Article
  14. Frontiers in cellular and infection microbiology · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monica C GestalDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Israel RiveraDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Laura K HowardDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Kalyan K DewanDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Illiassou Hamidou SoumanaDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Margaret DedloffDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Tracy L NicholsonUSDA ARS National Animal Disease Center, Ames, IA, United States.
Bodo LinzDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.

Funding

Evolution of the Bordetellae from Commensals to PathogensR01GM083113 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2008 to 2011
$2.1M
Systematic evaluation of B. pertussis ACT’s role as a protective antigenR01AI122753 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MAYNARD, JENNIFER A · 2016 to 2020
$1.9M
The Microbiota Pathogen CompetitionR01GM113681 · NIGMS · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2018
$1.3M
A Novel Polysaccharide Structure that Mediates TransmissionR21AI140399 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2018 to 2019
$413k
In vivo vaccine-driven evolution in Bordetella pertussisR21AI116186 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2016
$411k
Bordetella sp. Versus MicrobiotaR56AI107016 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2014 to 2014
$377k
NIAID NIH HHS HHSN272200900007CNIAID NIH HHS R01 AI122753NIAID NIH HHS R21 AI116186NIAID NIH HHS R21 AI140399NIAID NIH HHS R56 AI107016NIGMS NIH HHS R01 GM083113NIGMS NIH HHS R01 GM113681
6 · The paper itself

Abstract

The classical bordetellae sense and respond to a variety of environments outside and within their mammalian hosts. By causing inflammation and tissue damage, we reasoned that bordetellae are likely to encounter components of blood and/or serum during the course of a respiratory infection, and that detecting and responding to these would be advantageous. Therefore, we hypothesized that classical bordetellae have the ability to sense and respond to blood or serum. Blood or serum exposure resulted in substantial transcriptional changes in

Indexed as

Blood and Serum Responsive StimulonBordetellahost manipulationinflammationvirulence

Identifiers

PMID30245672
PMCPMC6137168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.