Evidence map›Paper›PMID 30245616›Full record

ReviewFrontiers in neuroscience2018

Totally Implantable Bidirectional Neural Prostheses: A Flexible Platform for Innovation in Neuromodulation.

Philip A Starr

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04958096 (Adjunct Cortical Stimulation With Deep Brain Stimulation), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04958096 narecruitingnot on this mapstarted 2021, after this paper: background citation

Adjunct Cortical Stimulation With Deep Brain Stimulation (DBS) to Treat Obsessive Compulsive Disorder (OCD)

TypeinterventionalSponsorAndrew Moses Lee, MD, PhDRan2021 to 2026Enrolled15ConditionsObsessive-Compulsive DisorderArmsStandard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Development and Evaluation of a Real-Time Phase-Triggered Stimulation Algorithm for the CorTec Brain Interchange.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024
    Article
  8. Article
  9. Article
  10. Mitigating Mismatch Compression in Differential Local Field Potentials.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Philip A StarrProfessor of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Neurological Surgery · US

Funding

Closed Loop Deep Brain Stimulation for Parkinson's DiseaseUH3NS100544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2016 to 2022
$4.1M
The motor network in Parkinson's disease: Mechanisms of therapyR01NS090913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2014 to 2023
$3.3M
NINDS NIH HHS R01 NS090913NINDS NIH HHS UH3 NS100544
6 · The paper itself

Abstract

Implantable neural prostheses are in widespread use for treating a variety of brain disorders. Until recently, most implantable brain devices have been unidirectional, either delivering neurostimulation without brain sensing, or sensing brain activity to drive external effectors without a stimulation component. Further, many neural interfaces that incorporate a sensing function have relied on hardwired connections, such that subjects are tethered to external computers and cannot move freely. A new generation of neural prostheses has become available, that are both bidirectional (stimulate as well as record brain activity) and totally implantable (no externalized connections). These devices provide an opportunity for discovering the circuit basis for neuropsychiatric disorders, and to prototype personalized neuromodulation therapies that selectively interrupt neural activity underlying specific signs and symptoms.

Indexed as

bidirectional interfacebrain-computer interfacebrain sensingdeep brain stimulationelectrocorticographylocal field potentialneural prosthesesoscillatory brain activity

Identifiers

PMID30245616
PMCPMC6137308
OpenAlexW2890134246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.