Evidence map›Paper›PMID 30245458›Full record

ArticleSeizure2018

Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla.

John W Rutland, Rebecca E Feldman, Bradley N Delman, Fedor Panov, Madeline C Fields, Lara V Marcuse, Patrick R Hof, Hung-Mo Lin, Priti Balchandani

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seizure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. UltraHigh Field MR Imaging in Epilepsy.Magnetic resonance imaging clinics of North America · 2021
    Review
  8. Article
  9. Article
  10. Ultrahigh field MR Neuroimaging.Topics in magnetic resonance imaging : TMRI · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

John W RutlandTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: jack.rutland@mssm.edu.
Rebecca E FeldmanTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Bradley N DelmanDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Fedor PanovDepartment of Neurosurgery, Mount Sinai Hospital, New York, NY, United States.
Madeline C FieldsDepartment of Neurology, Mount Sinai Hospital, New York, NY, United States.
Lara V MarcuseDepartment of Neurology, Mount Sinai Hospital, New York, NY, United States.
Patrick R HofDepartment of Neuroscience, Mount Sinai Hospital, New York, NY, United States.
Hung-Mo LinDepartment of Population Health Science and Policy, Mount Sinai Hospital, New York, NY, United States.
Priti BalchandaniTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Mount Sinai Hospital · USIcahn School of Medicine at Mount Sinai · US

Funding

7T MRI to reveal structural, connectomic and metabolic imaging markers for the neurobiology of depressionR01MH109544 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2016 to 2020
$2.1M
7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base TumorsR01CA202911 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2016 to 2020
$2.1M
High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7TR00NS070821 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2013 to 2015
$734k
High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7TK99NS070821 · NINDS · STANFORD UNIVERSITY · PI BALCHANDANI, PRITI · 2011 to 2012
$175k
NCI NIH HHS R01 CA202911NIMH NIH HHS R01 MH109544NINDS NIH HHS K99 NS070821NINDS NIH HHS R00 NS070821
6 · The paper itself

Abstract

purposeMRI-negative epilepsy patients could benefit from advanced imaging techniques such as high-resolution diffusion magnetic resonance imaging (dMRI). Our aim was to perform hippocampal subfield-specific tractography and quantify connectivity of the subfields in MRI-negative patients. Abnormal connectivity of the hippocampal subfields may help inform seizure focus hypothesis and provide information to guide surgical intervention.

methodsHippocampal structural imaging and dMRI was acquired in 25 drug resistant MRI-negative patients and 25 healthy volunteers. The hippocampi of each subject was segmented on high-resolution structural images and dMRI-based probabilistic tractography was performed in each subfield. The degrees of connectivity and fiber densities of the hippocampal subfields were quantified and compared between epilepsy patients and healthy volunteers.

resultsWe were able to perform subfield-specific hippocampal tractography in each subject that participated in this study. These methods identified some hippocampal subfields that are abnormally connected in MRI-negative patients. In particular patients suspected of left temporal seizure focus exhibited increased connectivity of certain ipsilateral subfields, especially the subiculum, presubiculum, and parasubiculum, and reduced connectivity of some contralateral subfields, such as CA1 and subiculum.

conclusionsOur data suggest that the hippocampal subfields are connected in distinct ways in different types of epilepsy. These results may provide important information that could help inform seizure focus hypothesis and in the surgical treatment of MRI-negative patients. These observations suggest that high-resolution dMRI-based tractography of the hippocampal subfields can detect subtle abnormalities in otherwise normal-appearing MRI-negative patients.

Indexed as

Image Processing, Computer-AssistedAdultAnisotropyDiffusion Tensor ImagingEpilepsy, Temporal LobeFemaleFunctional LateralityHippocampusHumansMaleMiddle AgedNerve FibersNeural PathwaysYoung AdultConnectivityDiffusion MRIDrug resistant epilepsyHippocampusMRI-negativeTractography

Identifiers

PMID30245458
PMCPMC6221989
OpenAlexW2891488970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.