Evidence map›Paper›PMID 30245329›Full record

ArticlePsychoneuroendocrinology2019

Pregnancy anxiety predicts shorter gestation in Latina and non-Latina white women: The role of placental corticotrophin-releasing hormone.

Isabel F Ramos, Christine M Guardino, Maxwell Mansolf, Laura M Glynn, Curt A Sandman, Calvin J Hobel, Christine Dunkel Schetter

Open access · greenAbstract read
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025
    Review
  7. Review
  8. Article
  9. A Call to Integrate Measures of Environmental Context into Research on Maternal Brain Health.International journal of environmental research and public health · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Associations of gestational age with gyrification and neurocognition in healthy adults.European archives of psychiatry and clinical neuroscience · 2023
    Article
  19. Article
  20. Anxiety in pregnancy and length of gestation: Findings from the healthy babies before birth study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Isabel F RamosUniversity of California, Los Angeles, United States. Electronic address: isabelramos@ucla.edu.
Christine M GuardinoDickinson College, United States.
Maxwell MansolfUniversity of California, Los Angeles, United States.
Laura M GlynnChapman University, United States; University of California, Irvine, United States.
Curt A SandmanUniversity of California, Irvine, United States.
Calvin J HobelUniversity of California, Los Angeles, United States; Cedars-Sinai Medical Center, United States.
Christine Dunkel SchetterUniversity of California, Los Angeles, United States. Electronic address: dunkel@psych.ucla.edu.
University of California, Los Angeles · USCedars-Sinai Medical Center · USChapman University · USDickinson College · USUniversity of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HIRAM BELTRAN-SANCHEZ · 2016 to 2026
$6.9M
PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Maternal Stress and Fetal/Infant DevelopmentR01NS041298 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2002 to 2006
$2.8M
Pregnancy Influences Environmental SensitivityR01HD040967 · NICHD · UNIVERSITY OF CALIFORNIA IRVINE · PI GLYNN, LAURA M · 2001 to 2005
$1.7M
NCATS NIH HHS UL1 TR001414NICHD NIH HHS P2C HD041022NICHD NIH HHS R01 HD040967NIMH NIH HHS T32 MH015750NINDS NIH HHS R01 NS041298
6 · The paper itself

Abstract

objectivePrevious research has shown that a woman's anxiety about her pregnancy predicts gestational length. Placental corticotrophin-releasing hormone (CRH) is a stress-responsive peptide proposed as a mechanism. We examined placental CRH as a physiological mediator of the association between pregnancy anxiety and gestational length in Latina and non-Latina White women to replicate evidence of associations between pregnancy anxiety, placental CRH and gestational length; to test whether placental CRH levels or changes mediate effects of pregnancy anxiety on gestational length; to examine ethnic differences in pregnancy anxiety, placental CRH, and gestational length; and to explore whether the effects of pregnancy anxiety on gestational length as mediated by placental CRH vary by ethnicity.

methodsIn a prospective study of 337 pregnant Latina and non-Latina White women, participants completed in-person interviews that included a 10-item measure of pregnancy anxiety and provided blood samples assayed using radioimmunoassay at three timepoints (19, 25, and 31 weeks gestation).

resultsPregnancy anxiety at 19 and 31 weeks and levels of placental CRH at 31 weeks predicted gestational length. Tests of indirect effects were consistent with mediation such that both pregnancy anxiety at 19 weeks and increases from 19 to 31 weeks predicted placental CRH at 31 weeks, which in turn predicted gestational length. Tests of moderated mediation by ethnicity showed that the mediated effect of placental CRH at 31 weeks was significant for Latinas only.

conclusionsThese findings add to growing evidence of the involvement of pregnancy anxiety in the timing of birth, address mechanisms, and suggest possible ethnic differences.

Indexed as

Gestational AgeAnxietyAnxiety DisordersBiomarkersCorticotropin-Releasing HormoneEthnicityFemaleHispanic or LatinoHumansParturitionPlacentaPregnancyProspective StudiesWhite PeopleBiomarkersCorticotropin-Releasing HormoneHPA-axisLength of gestationPreterm birth

Identifiers

PMID30245329
PMCPMC6231951
OpenAlexW2889631618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.