Evidence map›Paper›PMID 30244969›Full record

ArticleStructure (London, England : 1993)2018

Temperature-Induced Replacement of Phosphate Proton with Metal Ion Captured in Neutron Structures of A-DNA.

Venu Gopal Vandavasi, Matthew P Blakeley, David A Keen, Lillian R Hu, Zhen Huang, Andrey Kovalevsky

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Venu Gopal VandavasiNeutron Scattering Division, Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37922, USA.
Matthew P BlakeleyLarge Scale Structures Group, Institut Laue-Langevin, Grenoble 38000, France.
David A KeenISIS Facility, Rutherford Appleton Laboratory, Harwell Campus, Didcot OX11 0QX, UK.
Lillian R HuSeNA Research Inc., Atlanta, GA 30067, USA.
Zhen HuangDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Electronic address: huang@gsu.edu.
Andrey KovalevskyNeutron Scattering Division, Neutron Sciences Directorate, Oak Ridge National Laboratory, Oak Ridge, TN 37922, USA. Electronic address: kovalevskyay@ornl.gov.
Oak Ridge National Laboratory · USGeorgia State University · USInstitut Laue-Langevin · FRRutherford Appleton Laboratory · GBSeNA Research (United States) · US

Funding

Selenium-Derivatized RNAs and DNAs for High-Throughput Protein/Nucleic Acid CrystR01GM095881 · NIGMS · GEORGIA STATE UNIVERSITY · PI HUANG, ZHEN · 2012 to 2016
$1.4M
Selenium-derivatized New Reagents for Nucleic Acid X-ray CrystallographyR42ES026935 · NIEHS · SENA RESEARCH, INC. · PI HUANG, ZHEN · 2015 to 2016
$1.1M
NIEHS NIH HHS R42 ES026935NIGMS NIH HHS R01 GM095881
6 · The paper itself

Abstract

Nucleic acids can fold into well-defined 3D structures that help determine their function. Knowing precise nucleic acid structures can also be used for the design of nucleic acid-based therapeutics. However, locations of hydrogen atoms, which are key players of nucleic acid function, are normally not determined with X-ray crystallography. Accurate determination of hydrogen atom positions can provide indispensable information on protonation states, hydrogen bonding, and water architecture in nucleic acids. Here, we used neutron crystallography in combination with X-ray diffraction to obtain joint X-ray/neutron structures at both room and cryo temperatures of a self-complementary A-DNA oligonucleotide d[GTGG(C

Indexed as

Crystallography, X-RayDNA, A-FormHydrogen BondingModels, MolecularNeutron DiffractionNucleic Acid ConformationPhosphatesProtonsTemperatureDNA, A-FormPhosphatesProtonsA-form DNAhydrogen bondingmetal bindingneutron crystallographyoligonucleotide crystallizationprotonationRNAselenium modification and derivatization

Identifiers

PMID30244969
PMCPMC6281803
OpenAlexW2890696136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.