Evidence map›Paper›PMID 30244966›Full record

ArticleStructure (London, England : 1993)2018

Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP

Benedikt Goretzki, Nina A Glogowski, Erika Diehl, Elke Duchardt-Ferner, Carolin Hacker, Rachelle Gaudet, Ute A Hellmich

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. TRPV4 Channel Modulators as Potential Drug Candidates for Cystic Fibrosis.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. TRPV4: A trigger of pathological RhoA activation in neurological disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  13. Article
  14. Article
  15. PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022
    Review
  16. Article
  17. TRPing on Cell Swelling - TRPV4 Senses It.Frontiers in immunology · 2021
    Review
  18. A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  19. Review
  20. Polymodal Sensory Transduction in Mouse Corneal Epithelial Cells.Investigative ophthalmology & visual science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Benedikt GoretzkiInstitute for Pharmacy and Biochemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany.
Nina A GlogowskiInstitute for Pharmacy and Biochemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany.
Erika DiehlInstitute for Pharmacy and Biochemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany.
Elke Duchardt-FernerCenter for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany; Institute for Molecular Biosciences, Goethe-Universität, 60438 Frankfurt am Main, Germany.
Carolin HackerCenter for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany; Institute for Molecular Biosciences, Goethe-Universität, 60438 Frankfurt am Main, Germany.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Ute A HellmichInstitute for Pharmacy and Biochemistry, Johannes Gutenberg-Universität Mainz, 55128 Mainz, Germany; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, 60438 Frankfurt am Main, Germany. Electronic address: u.hellmich@uni-mainz.de.
Johannes Gutenberg University Mainz · DEGoethe University Frankfurt · DEHarvard University · US

Funding

Structure and Function of TRPV Ion ChannelsR01GM081340 · NIGMS · HARVARD UNIVERSITY · PI GAUDET, RACHELLE · 2008 to 2012
$1.6M
NIGMS NIH HHS R01 GM081340
6 · The paper itself

Abstract

Transient receptor potential (TRP) channels are polymodally regulated ion channels. TRPV4 (vanilloid 4) is sensitized by PIP

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBinding SitesChickensCircular DichroismHumansMagnetic Resonance SpectroscopyModels, MolecularPhosphatidylinositol 4,5-DiphosphatePhosphoproteinsProtein DomainsTRPV Cation ChannelsAdaptor Proteins, Signal TransducingPhosphatidylinositol 4,5-DiphosphatePhosphoproteinsTRPV Cation Channelscis prolineclass INMRPACSINPIP(2)proline-rich regionSH3 domainSyndapinTRP channelTRPV4

Identifiers

PMID30244966
PMCPMC6281781
OpenAlexW2891183577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.