Evidence map›Paper›PMID 30244834›Full record

ArticleMolecular cell2018

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands.

Haiyun Gan, Albert Serra-Cardona, Xu Hua, Hui Zhou, Karim Labib, Chuanhe Yu, Zhiguo Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 193 citations in OpenAlex.

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  13. DNA polymerase α-primase can function as a translesion DNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2025
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Haiyun GanInstitute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Albert Serra-CardonaInstitute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Xu HuaInstitute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Hui ZhouInstitute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Karim LabibMRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Chuanhe YuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: yu.chuanhe@mayo.edu.
Zhiguo ZhangInstitute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: zz2401@cumc.columbia.edu.
Cancer Genetics (United States) · USColumbia University · USMRC Protein Phosphorylation and Ubiquitylation Unit · GBWinnMed · US

Funding

Mechanisms of Epigenetic inheritanceR35GM118015 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Zhiguo Zhang · 2016 to 2026
$9.5M
Role of nucleosome dynamics in epigenetic inheritanceR01GM130588 · NIGMS · UNIVERSITY OF MINNESOTA · PI YU, CHUANHE · 2019 to 2023
$1.7M
Medical Research Council MC_UU_00018/4Medical Research Council MC_UU_12016/13NIGMS NIH HHS R01 GM130588NIGMS NIH HHS R35 GM118015Wellcome Trust 102943/Z/13/Z
6 · The paper itself

Abstract

Although essential for epigenetic inheritance, the transfer of parental histone (H3-H4)

Indexed as

Chromatin Assembly and DisassemblyDNA-Binding ProteinsDNA HelicasesDNA Polymerase IIIDNA ReplicationEpigenesis, GeneticHistonesMultiprotein ComplexesNucleosomesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCTF4 protein, S cerevisiaeDNA-Binding ProteinsDNA HelicasesDNA polymerase ADNA Polymerase IIIHistonesMCM2 protein, S cerevisiaeMultiprotein ComplexesNucleosomesSaccharomyces cerevisiae ProteinsCtf4DNA replicationepigenetic inheritancehistone modificationsMcm2nucleosome assemblyparental histone transferPol1

Identifiers

PMID30244834
PMCPMC6193272
OpenAlexW2889812869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.