Evidence map›Paper›PMID 30244678›Full record

Observational studyCritical care (London, England)2018

Net ultrafiltration intensity and mortality in critically ill patients with fluid overload.

Raghavan Murugan, Vikram Balakumar, Samantha J Kerti, Priyanka Priyanka, Chung-Chou H Chang, Gilles Clermont, Rinaldo Bellomo, Paul M Palevsky, John A Kellum

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05306964 naterminatednot on this mapstarted 2022, after this paper: background citation

REstrictive Versus LIberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury

TypeinterventionalSponsorUniversity of PittsburghRan2022 to 2024Enrolled99ConditionsAcute Kidney Injury, Fluid Overload, Hypotension, DialysisArmsRestrictive UFnet Rate Strategy, Liberal UFnet Rate Strategy
NCT06071026 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of the Hemodynamic Effect of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy Sessions for Acute Renal Failure in Intensive Care Patients. Multiple N-of-1 Randomised Bi-centric Controlled Trial.

TypeinterventionalSponsorCentre Hospitalier Universitaire de NīmesRan2023 to 2025Enrolled39ConditionsFluid Overload, Hemodynamic InstabilityArmsNet Ultra Filtration Rate
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Trial
  4. Trial
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  6. Article
  7. Review
  8. Article
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  13. Review
  14. Article
  15. Observational
  16. Article
  17. Professor Rinaldo Bellomo: Founder, architect, and choreographer of critical care nephrology.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Review
  18. Review
  19. [The ROSE concept: modern fluid management in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Raghavan MuruganDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. muruganr@upmc.edu.ORCID http://orcid.org/0000-0002-6823-6365
Vikram BalakumarDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Samantha J KertiDepartment of Critical Care Medicine, The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Priyanka PriyankaDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Chung-Chou H ChangDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Gilles ClermontDepartment of Critical Care Medicine, The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Rinaldo BellomoDepartment of Intensive Care Medicine, The University of Melbourne, Austin Hospital, Heidelberg, VIC, Australia.
Paul M PalevskyDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
John A KellumDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, CRISMA, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough net ultrafiltration (UF

methodsWe selected patients with fluid overload ≥ 5% of body weight prior to initiation of RRT from a large academic medical center ICU dataset. UF

resultsOf 1075 patients, the distribution of high, moderate and low-intensity UF

conclusionsAmong critically ill patients with ≥ 5% fluid overload and receiving RRT, UF

Indexed as

Acute Kidney InjuryAgedAPACHEBody WeightCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedMortalityProspective StudiesRenal Replacement TherapyRetrospective StudiesUltrafiltrationWater-Electrolyte BalanceDialysisFluid overloadIntensityMortalityNet ultrafiltrationRenal replacement therapy

Identifiers

PMID30244678
PMCPMC6151928

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.