ArticlePlant molecular biology2018
Evolutionary divergence of the rye Pm17 and Pm8 resistance genes reveals ancient diversity.
Article in Plant molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Agronomic Performance and Dual Resistance Evaluation to Powdery Mildew and Stripe Rust in 660 Wheat Germplasm Lines.Plants (Basel, Switzerland) · 2026Article
- Mapping and marker development of the rye-derived Hessian fly resistance gene H25 in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Comparative Proteomic Analysis Reveals That TaCAD-A1 Enhances Resistance of Wheat to Powdery Mildew (Life (Basel, Switzerland) · 2026Article
- Fine mapping and candidate gene identification of the stripe rust resistance gene Yr83 using mutated wheat-rye translocation lines.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors.Nature plants · 2026Article
- Characterization and genetic dissection of the powdery mildew resistance in cultivated emmer wheat accession L424.BMC plant biology · 2025Article
- Paired NLRs originated from Triticum dicoccoides coordinately confer resistance to powdery mildew in wheat.Nature communications · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Genetic Basis Identification of aPlants (Basel, Switzerland) · 2025Article
- Fine mapping of a novel powdery mildew resistance gene PmDM8 derived from a cultivated emmer (Triticum dicoccum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Population genomics and molecular epidemiology of wheat powdery mildew in Europe.PLoS biology · 2025Article
- Progress and innovations of gene cloning in wheat and its close relatives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew.Plant biotechnology journal · 2025Article
- Fine mapping of stripe rust resistance gene YrAn1589 in common wheat using Wheat660K SNP array and BSR-Seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Avirulence depletion assay: Combining R gene-mediated selection with bulk sequencing for rapid avirulence gene identification in wheat powdery mildew.PLoS pathogens · 2025Article
- Cytological mapping of a powdery mildew resistance locus PmRc1 based on wheat-Roegneria ciliaris structural rearrangement library.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Development and Characterization of Two Wheat-Rye Introgression Lines with Resistance to Stripe Rust and Powdery Mildew.International journal of molecular sciences · 2024Article
- Genetic Basis Identification of aInternational journal of molecular sciences · 2024Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
key messageWe have isolated a novel powdery mildew resistance gene in wheat that was originally introgressed from rye. Further analysis revealed evolutionary divergent history of wheat and rye orthologous resistance genes. Wheat production is under constant threat from a number of fungal pathogens, among them is wheat powdery mildew (Blumeria graminis f. sp. tritici). Deployment of resistance genes is the most economical and sustainable method for mildew control. However, domestication and selective breeding have narrowed genetic diversity of modern wheat germplasm, and breeders have relied on wheat relatives for enriching its gene pool through introgression. Translocations where the 1RS chromosome arm was introgressed from rye to wheat have improved yield and resistance against various pathogens. Here, we isolated the Pm17 mildew resistance gene located on the 1RS introgression in wheat cultivar 'Amigo' and found that it is an allele or a close paralog of the Pm8 gene isolated earlier from 'Petkus' rye. Functional validation using transient and stable transformation confirmed the identity of Pm17. Analysis of Pm17 and Pm8 coding regions revealed an overall identity of 82.9% at the protein level, with the LRR domains being most divergent. Our analysis also showed that the two rye genes are much more diverse compared to the variants encoded by the Pm3 gene in wheat, which is orthologous to Pm17/Pm8 as concluded from highly conserved upstream sequences in all these genes. Thus, the evolutionary history of these orthologous loci differs in the cereal species rye and wheat and demonstrates that orthologous resistance genes can take different routes towards functionally active genes. These findings suggest that the isolation of Pm3/Pm8/Pm17 orthologs from other grass species, additional alleles from the rye germplasm as well as possibly synthetic variants will result in novel resistance genes useful in wheat breeding.
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