Evidence map›Paper›PMID 30244312›Full record

ArticleJournal of youth and adolescence2019

Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.

Gabriel L Schlomer, H Harrington Cleveland, Arielle R Deutsch, David J Vandenbergh, Mark E Feinberg, Mark T Greenberg, Richard L Spoth, Cleve Redmond

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of youth and adolescence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel L SchlomerDivision of Educational Psychology and Methodology, University at Albany, State University of New York, Albany, NY, USA. gschlomer@albany.edu.ORCID http://orcid.org/0000-0002-6110-3076
H Harrington ClevelandDepartment of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA.
Arielle R DeutschSanford Research, Sioux Falls, SD, USA.
David J VandenberghDepartment of Biobehavioral Health, Huck Institute for the Neurosciences, Molecular Cellular & Integrative Biosciences Program, The Pennsylvania State University, University Park, PA, USA.
Mark E FeinbergPrevention Research Center, The Pennsylvania State University, University Park, PA, USA.
Mark T GreenbergDepartment of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA.
Richard L SpothPartnerships in Prevention Science Institute, Iowa State University, Ames, IA, USA.
Cleve RedmondPartnerships in Prevention Science Institute, Iowa State University, Ames, IA, USA.

Funding

Partnership Model for Diffusion of Proven PreventionR01DA013709 · NIDA · IOWA STATE UNIVERSITY · PI SPOTH, RICHARD · 2002 to 2017
$35.0M
Implications of Genetic Variance for Substance Use Interventions in AdolescenceR01DA030389 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI CLEVELAND, HOBART HARRINGTON, VANDENBERGH, DAVID J · 2011 to 2014
$2.2M
NIDA NIH HHS DA030389NIDA NIH HHS R01 DA013709NIDA NIH HHS R01 DA030389
6 · The paper itself

Abstract

Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.

Indexed as

Juvenile DelinquencyAdolescentAlcohol DrinkingAlcoholismAllelesAntisocial Personality DisorderFemaleHaplotypesHumansMalePolymorphism, Single NucleotideReceptors, GABA-AGABRA2 protein, humanReceptors, GABA-ADelinquencyGABRA2GeneticGxEIntervention

Identifiers

PMID30244312
PMCPMC10507654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.