ArticleCancer causes & control : CCC2018
Risk of colon cancer recurrence in relation to diabetes.
Article in Cancer causes & control : CCC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Patient and tumour characteristics of screening-age adults diagnosed with screen-detected versus symptomatic colon cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Core concepts in pharmacoepidemiology: Violations of the positivity assumption in the causal analysis of observational data: Consequences and statistical approaches.Pharmacoepidemiology and drug safety · 2021Review
- Characterizing Bias Due to Differential Exposure Ascertainment in Electronic Health Record Data.Health services & outcomes research methodology · 2021Article
- The effect of smoking, obesity and diabetes on recurrence-free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy.Cancer reports (Hoboken, N.J.) · 2021Article
- Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environmentJournal of gastrointestinal oncology · 2020Article
- Recurrence Risk after Radical Colorectal Cancer Surgery-Less Than before, But How High Is It?Cancers · 2020Review
- Changes in use of opioid therapy after colon cancer diagnosis: a population-based study.Cancer causes & control : CCC · 2019Article
- Obesity, diabetes and the risk of colorectal adenoma and cancer.BMC endocrine disorders · 2019Article
- Use of antidepressants after colon cancer diagnosis and risk of recurrence.Psycho-oncology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo describe the association between diabetes and colon cancer recurrence.
methodsWe conducted a cohort study at two integrated health care delivery systems in the United States. Using tumor registry data, we identified patients aged ≥ 18 years when diagnosed with stage I-IIIA adenocarcinomas of the colon during 1995-2014. Pre-existing diabetes was ascertained via diagnosis codes. Medical records were reviewed for eligibility and to abstract recurrence and covariate information. Recurrence was ascertained beginning 90 days after the end of colon cancer treatment (i.e., cohort entry). Recurrence of any cancer or a new primary cancer at any site was a secondary outcome. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CIs) for the associations between diabetes at cohort entry and study outcomes.
resultsAmong the 1,923 eligible patients, 393 (16.7%) had diabetes at cohort entry. Diabetes was not associated with recurrence (HR 0.87; 95% CI 0.56-1.33) or with any subsequent cancer (HR 1.09; 95% CI 0.85-1.40). When the definition of recurrence included second primary colorectal cancer, risk was non-significantly higher in patients with diabetes than without diabetes.
conclusionsThe risk of colon cancer recurrence appears to be similar in patients with and without diabetes at diagnosis. IMPACT: Future studies should evaluate the association between diabetes and colorectal cancer outcomes, especially second primary colon cancers, in larger populations.
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