Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2019
The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer-a randomized-controlled trial.
Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- ASYMPTOMATIC CHOLELITHIASIS: EXPECTANT OR CHOLECYSTECTOMY. A SYSTEMATIC REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Pooled it
- Prophylactic cholecystectomy: A valuable treatment strategy for cholecystolithiasis after gastric cancer surgery.Frontiers in oncology · 2022Pooled it
- Impact of concomitant cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life.Surgery today · 2026Article
- Incidence and risk factors for symptomatic gallstone disease after gastrectomy for gastric cancer: a nationwide population-based study.International journal of surgery (London, England) · 2026Article
- A history of gastrectomy is a risk factor for choledocholithiasis in patients undergoing cholecystectomy: A single center retrospective study.Annals of gastroenterological surgery · 2025Article
- How to identify early complications in patients undergoing distal gastrectomy?World journal of gastrointestinal surgery · 2024Article
- Gallstone formation and subsequent cholecystectomy after oncological gastric and esophageal resection.Langenbeck's archives of surgery · 2024Article
- Comparison Study between ERCP and PTBD for Recurrent Choledocholithiasis in Patients Following Gastrectomy.Diagnostics (Basel, Switzerland) · 2023Article
- Supra-ampullary duodenectomy in a patient with positive distal resection margin after subtotal gastrectomy for gastric cancer: a case report.Korean journal of clinical oncology · 2023Article
- Significance of cholecystectomy in cytoreductive surgery for advanced ovarian cancer.BMC surgery · 2023Article
- A Robotic Completely Intercorporeal Jejunal Pouch Reconstruction after Gastrectomy.Current oncology (Toronto, Ont.) · 2022Article
- Clinical Characteristics of Symptomatic Cholecystitis in Post-Gastrectomy Patients: 11 Years of Experience in a Single Center.Medicina (Kaunas, Lithuania) · 2022Review
- Treatment of a duodenal-caval fistula secondary to peptic ulcer disease.Journal of vascular surgery cases and innovative techniques · 2022Article
- Early gastric cancer: A challenge in Western countries.World journal of gastroenterology · 2022Article
- Postoperative mortality and morbidity after D2 lymphadenectomy for gastric cancer: A retrospective cohort study.World journal of gastroenterology · 2022Article
- Important risk factors for gallstones after laparoscopic gastrectomy: a retrospective study.BMC surgery · 2022Article
- Essential updates 2019/2020: Perioperative and surgical management of gastric cancer.Annals of gastroenterological surgery · 2021Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of cholelithiasis has been shown to be higher for patients after gastrectomy than for the general population, due to vagal branch damage and gastrointestinal reconstruction. The aim of this trial was to evaluate the need for routine concomitant prophylactic cholecystectomy (PC) during gastrectomy for cancer.
methodsA multicenter, randomized, controlled trial was conducted between November 2008 and March 2017. Of the total 130 included patients, 65 underwent PC and 65 underwent standard gastric surgery only for curable cancers. The primary endpoint was cholelithiasis-free survival after gastrectomy for gastric adenocarcinoma. Cholelithiasis was detected by ultrasound exam.
resultsAfter a median follow-up of 62 months, eight patients (12.3%) in the control group developed biliary abnormalities (four cases of gallbladder calculi and four cases of biliary sludge), with only three (4.6%) being clinically relevant (two cholecystectomies needed, one acute pancreatitis). One patient in the PC group had asymptomatic biliary dilatation during sonography after surgery. The cholelithiasis-free survival did not show statistical significance between the two groups (P = 0.267). The number needed to treat with PC to avoid reoperation for cholelithiasis was 1:32.5.
conclusionsConcomitant PC during gastric surgery for malignancies, although reducing the absolute number of biliary abnormalities, has no significant impact on the natural course of patients.
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