Evidence map›Paper›PMID 30244292›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2018

Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions.

María F Zappa Villar, Juliette López Hanotte, Eugenia Falomir Lockhart, Lucía S Trípodi, Gustavo R Morel, Paula C Reggiani

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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María F Zappa VillarInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina.
Juliette López HanotteInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina.
Eugenia Falomir LockhartInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina.
Lucía S TrípodiInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina.
Gustavo R MorelInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina.
Paula C ReggianiInstitute for Biochemical Research (INIBIOLP)-Cathedra of Histology B, School of Medical Sciences, National University of La Plata (UNLP), CC 455, Zip 1900, La Plata, Argentina. paulareggiani@conicet.gov.ar.ORCID 0000-0003-3784-3864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sporadic Alzheimer's disease (SAD) is the most common form of dementia; therefore, there is an urgent need for a model that recapitulates the main pathologic hallmarks of this disease. The intracerebroventricular (icv) injection of streptozotocin (icv-STZ) in rats constitutes a promising model, and thus, icv-STZ rats develop insulin-resistant brain state and cognitive impairments. Even though a great piece of studies has hitherto described this system as a model for SAD, further behavioral and morphometric studies are still needed to fully characterize it. In this study, using Sprague Dawley rats, we evaluated short-term effects on behavior and hippocampus morphometry of the icv-STZ injection at two doses: 1 (STZ1) and 3 mg/kg (STZ3). We found that, following icv-STZ injection, STZ3 animals, but not STZ1, exhibited impairments in spatial reference learning and memory (Barnes maze test) and in recognition memory (object recognition test). Furthermore, the results from behavioral and morpho-histochemical data are compatible. STZ3 rats displayed Stratum Radiatum volume reduction and a decreased NeuN immunoreactivity (neuron loss) in hippocampal CA1 region, together with an increased immunoreactivity for microglial (Iba1) and astroglial (GFAP) markers (neuroinflammation). Sholl analysis revealed the vulnerability of hippocampal astrocytes to STZ in CA1 and CA3. Thus, both doses induced a reduction in process length and in the number of main processes, accompanied by a frank decrease in branching complexity. The present study provides important knowledge of this AD rat model. Overall, we found that the only high STZ dose induced severe and acute neurodegenerative lesions, associated with an inflammation process.

Indexed as

AnimalsAstrocytesCA1 Region, HippocampalCA3 Region, HippocampalCell ShapeInjections, IntraventricularMaleMaze LearningRatsRats, Sprague-DawleySpatial MemoryStreptozocinStreptozocinAstrocyte-branching complexityHippocampal morphologyNon-transgenic rat modelSpatial memorySporadic Alzheimer’s diseaseStreptozotocin

Identifiers

PMID30244292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.