Evidence map›Paper›PMID 30244215›Full record

ArticleBMJ open2018

Hepatitis B virus contact disclosure and testing in Lusaka, Zambia: a mixed-methods study.

Sarah Franklin, Amina Mouliom, Edford Sinkala, Annie Kanunga, Anna Helova, Jodie Dionne-Odom, Janet M Turan, Michael Vinikoor

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03158818 (Chronic Hepatitis B Virus Infection in Zambia), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03158818 completednot on this map

Chronic Hepatitis B Virus Infection in Zambia: a Prospective Clinical Cohort Study

TypeobservationalSponsorUniversity of Alabama at BirminghamRan2016 to 2024Enrolled326ConditionsHBV, Fibrosis, Liver, Cirrhosis, Liver, Alcoholic HepatitisArmsStandard of care
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Social challenges experienced by Hepatitis B patients: A mixed method study.Journal of family medicine and primary care · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah Franklin *School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4988-6271
Amina Mouliom *School of Pharmacy, Southwestern Oklahoma State University, Weatherford, Oklahoma, USA.
Edford SinkalaTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
Annie KanungaTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.
Anna HelovaSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jodie Dionne-OdomDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Janet M TuranSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Michael VinikoorTropical Gastroenterology and Nutrition Group, University of Zambia, Lusaka, Zambia.

Funding

UAB Public Health/Biomedical Research Training ProgramT37MD001448 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JOLLY, PAULINE EVADNE · 2005 to 2024
$4.8M
A Novel Regimen to Prevent Malaria and STIs in Pregnant Women with HIVK23HD090993 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DIONNE, JODIE ANN · 2016 to 2020
$840k
Impact of antiretroviral therapy on liver fibrosis in Zambian HIV/HBV patientsK01TW009998 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VINIKOOR, MICHAEL JEFFREY · 2014 to 2017
$526k
FIC NIH HHS K01 TW009998NICHD NIH HHS K23 HD090993NIMHD NIH HHS T37 MD001448
6 · The paper itself

Abstract

objectivesThe aim of this study was to estimate the frequency of disclosure to and testing of contacts of patients with hepatitis B virus (HBV) in Zambia.

designWe used a convergent parallel mixed-method research design including a quantitative survey and focus group discussions with patients with HBV.

settingA university hospital in Lusaka, Zambia.

participants79 hepatitis B surface antigen (HBsAg)-positive, HIV-negative, adults (18+ years) receiving HBV care completed a quantitative survey and 32 also participated in a focus group discussion. OUTCOMES AND ANALYSIS: Contacts of patients with HBV were enumerated and patient-reported disclosure, contact testing and contact HBV test results were used to develop a testing cascade. Using multivariable logistic regression, we identified factors associated with disclosure of HBV status. In focus groups, we explored how index patient knowledge and awareness of their condition shaped perspectives on contact disclosure and testing. Focus groups coding and analysis followed a thematic analysis approach.

resultsAmong 79 patients with HBV (median age 35 years; 26.6% women), the majority reported disclosure to ≥1 contact. According to the index patients' knowledge, of 776 contacts enumerated, 326 (42.1%) were disclosed to, 77 (9.9%) were tested, 67 (8.6%) received results and 8 (11.9%) were HBsAg-positive. Increased stigma score was associated with reduced disclosure. In focus groups, HBV awareness, knowledge and stigma emerged as barriers to disclosure and referral of contacts for testing. Association of HBV with HIV-related stigma was also reported as a strong barrier to contact disclosure and testing and to taking antivirals for HBV monoinfection.

conclusionsHBV contact disclosure and testing were feasible and yielded new diagnoses in Zambia. A better understanding of barriers to seeking HBV testing and treatment is needed to scale-up this important intervention in Africa. TRIALS REGISTRATION NUMBER: NCT03158818.

Indexed as

Communication BarriersContact TracingHepatitis BAdultCohort StudiesDisclosureFemaleFocus GroupsHumansMalePatient Acceptance of Health CareSensitivity Training GroupsSocial StigmaVirologyZambiacontact testing and disclosurehepatitis B virusstigmasub-saharan africa

Identifiers

PMID30244215
PMCPMC6157559

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.