ArticleBMJ open2018
Increased risk of aortic aneurysm and dissection in patients with Sjögren's syndrome: a nationwide population-based cohort study in Taiwan.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Inflammatory Aortopathies in Rheumatic Diseases: A State-of-the-Art Review.Diagnostics (Basel, Switzerland) · 2026Review
- Saccular common iliac artery aneurysm associated with HLA-A26 and HLA-B27 in a young adult patient: a surgical case report and literature review.General thoracic and cardiovascular surgery cases · 2026Article
- Pancreaticoduodenal artery aneurysms and cerebral aneurysms in a patient of Sjögren's syndrome: a surgical case report and literature review.General thoracic and cardiovascular surgery cases · 2026Article
- Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment.Journal of cardiovascular development and disease · 2025Review
- Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Causal associations of Sjögren's syndrome with cardiovascular disease: A two-sample Mendelian randomization study.American heart journal plus : cardiology research and practice · 2024Article
- Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored.Frontiers in immunology · 2022Review
- Article
- Cardiovascular Disease in Primary Sjögren's Syndrome: Raising Clinicians' Awareness.Frontiers in immunology · 2022Review
- Investigation of the Impact of Endodontic Therapy on Survival among Dialysis Patients in Taiwan: A Nationwide Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- Association Between Autoimmune Diseases and Spontaneous Cervicocranial Arterial Dissection.Frontiers in immunology · 2021Article
- Zone 0 Thoracic Endovascular Aortic Repair Using Reverse Extra-Anatomical Aortic Arch Debranching Technique for an Anastomotic Pseudoaneurysm and Acute Aortic Dissection that Developed after Bentall's Surgery Combined with Sjögren's Syndrome.Annals of vascular diseases · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSjögren's syndrome (SS) is a systemic autoimmune disorder. Several molecular pathways and the activation of matrix metalloproteinases associated with the pathogenesis of SS participate in the initiation and progression of aortic aneurysm (AA) and aortic dissection (AD). In this study, we aimed to evaluate whether patients with SS exhibit an increased risk of AA or AD.
methodsWe conducted a retrospective cohort study using a database extracted from Taiwan's National Health Insurance Research Database. All medical conditions for each case and control were categorised using the International Classification of Diseases, Ninth Revision. HRs and 95% CIs for associations between SS and AA/AD were estimated using Cox regression and adjusted for comorbidities.
resultsOur analyses included 10 941 SS cases and 43 764 propensity score-matched controls. Compared with the controls, the patients with SS exhibited a significantly increased risk of developing an AA or AD (adjusted HR=3.642, p<0.001). Subgroup analysis revealed that compared with patients without SS, patients with primary and secondary SS both exhibited a significantly increased risk of developing AA or AD (adjusted HR=1.753, p=0.042; adjusted HR=3.693, p<0.001).
conclusionPatients with SS exhibit increased risks of developing AA or AD, and healthcare professionals should be aware of this risk when treating patients with SS. Increased aortic surveillance may be required for patients with SS.
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