Evidence map›Paper›PMID 30243853›Full record

Trial reportSchizophrenia research2019

Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial.

Tate Halverson, L Fredrik Jarskog, Cort Pedersen, David Penn

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Racial disparities and predictors of functioning in schizophrenia.The American journal of orthopsychiatry · 2023
    Article
  8. Review
  9. Oxytocin administration versus emotion training in healthy males: considerations for future research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Tate HalversonUniversity of North Carolina at Chapel Hill, Department of Psychology and Neuroscience, Davie Hall (CB #3270), Chapel Hill, NC 27599, USA. Electronic address: tate.halverson@unc.edu.
L Fredrik JarskogUniversity of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, NC, 101 Manning Drive (CB#7160), Chapel Hill, NC 27599, USA; University of North Carolina at Chapel Hill, North Carolina Psychiatric Research Center, 3010 Falstaff Road, Raleigh, NC 27610, USA.
Cort PedersenUniversity of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, NC, 101 Manning Drive (CB#7160), Chapel Hill, NC 27599, USA.
David PennUniversity of North Carolina at Chapel Hill, Department of Psychology and Neuroscience, Davie Hall (CB #3270), Chapel Hill, NC 27599, USA; Australian Catholic University, School of Psychology, Locked Bag 4115 Fitzroy MDC Fitzroy Victoria 3065, Melbourne, VIC, Australia.
University of North Carolina at Chapel Hill · US

Funding

Oxytocin Treatment of Social Cognitive and Functional Deficits in SchizophreniaR01MH093529 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDERSEN, CORT ANDREW, PENN, DAVID LEWIS · 2011 to 2013
$1.6M
NIMH NIH HHS R01 MH093529
6 · The paper itself

Abstract

The effects of intranasal oxytocin, a neuropeptide involved in prosocial behavior and modulation of neural networks underlying social cognition and emotion regulation, have been studied in schizophrenia. We tested the hypothesis that twice-daily intranasal oxytocin administered for 12-weeks would improve tertiary and exploratory outcomes of self-reported social symptoms, empathy and introspective accuracy from the Jarskog et al. (2017) randomized controlled trial. Sixty-eight stable outpatients with schizophrenia or schizoaffective disorder were randomized to receive oxytocin (24 IU twice daily) or placebo. Introspective accuracy was assessed with the Specific Level of Functioning Scale and the Interpersonal Perception Task. Empathy was assessed with the Interpersonal Reactivity Index (IRI), and social symptoms were assessed with the Liebowitz Social Anxiety Scale and the Green et al. Paranoid Thoughts Scales. Outcomes were assessed at baseline, six, and twelve weeks. Results demonstrated limited effect of oxytocin with some improvement on the IRI Perspective-Taking Subscale. No additional between-group differences emerged on self-reported symptoms, empathy, or introspective accuracy.

Indexed as

Social BehaviorSocial PerceptionAdministration, IntranasalAdultEmpathyFemaleHumansMaleMiddle AgedOxytocinPsychotic DisordersSchizophreniaTreatment OutcomeOxytocinOxytocinPsychosisSchizoaffective disorderSchizophreniaSocial behavior

Identifiers

PMID30243853
PMCPMC6402996
OpenAlexW2889908755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.