Evidence map›Paper›PMID 30243621›Full record

ArticleGastroenterology2019

Earlier Colorectal Cancer Screening May Be Necessary In Patients With Li-Fraumeni Syndrome.

Suzanne P MacFarland, Kristin Zelley, Jessica M Long, Danielle McKenna, Petar Mamula, Susan M Domchek, Katherine L Nathanson, Garrett M Brodeur, Anil K Rustgi, Bryson W Katona and 1 more

Abstract read
In one paragraph

Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Spectrum and Excess Risk of Gastrointestinal Tumors in Li-Fraumeni Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. A RareCancer research · 2020
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Suzanne P MacFarlandDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Kristin ZelleyDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jessica M LongDivision of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Danielle McKennaDivision of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Petar MamulaDivision of Gastroenterology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Susan M DomchekDivision of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Katherine L NathansonDivision of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Garrett M BrodeurDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Anil K RustgiDivision of Gastroenterology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Bryson W KatonaDivision of Gastroenterology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: bryson.katona@uphs.upenn.edu.
Kara N MaxwellDivision of Gastroenterology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Physician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5M
A genotype-phenotype study of tumors from patients with inherited mutations in DNA repair genesK08CA215312 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAXWELL, KARA N · 2018 to 2022
$924k
Menin/MLL promotes cell survival in the setting of EGFR inhibitionK08DK106489 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATONA, BRYSON WILLIAM · 2015 to 2019
$819k
NCI NIH HHS K08 CA215312NCI NIH HHS K12 CA076931NIDDK NIH HHS K08 DK106489
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAge of OnsetColorectal NeoplasmsDatabases, FactualEarly Detection of CancerGenetic Predisposition to DiseaseHumansIncidenceLi-Fraumeni SyndromeMaleMiddle AgedMutationPhenotypePhiladelphiaPredictive Value of TestsTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID30243621
PMCPMC6309491
OpenAlexW2890331799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.