Evidence map›Paper›PMID 30243300›Full record

ReviewCritical care (London, England)2018

The global burden of sepsis: barriers and potential solutions.

Kristina E Rudd, Niranjan Kissoon, Direk Limmathurotsakul, Sotharith Bory, Birungi Mutahunga, Christopher W Seymour, Derek C Angus, T Eoin West

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  9. Norepinephrine in Septic Shock: A Systematic Review and Meta-analysis.The western journal of emergency medicine · 2021
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristina E RuddInternational Respiratory and Severe Illness Center, University of Washington, Seattle, WA, USA. ruddk@pitt.edu.ORCID 0000-0002-6695-8401
Niranjan KissoonDivision of Critical Care, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital, Vancouver, BC, Canada.
Direk LimmathurotsakulMahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Sotharith BoryDivision of Infectious Diseases, Department of Medicine, Calmette Hospital, Phnom Penh, Cambodia.
Birungi MutahungaBwindi Community Hospital, Kanungu, Uganda.
Christopher W SeymourDepartments of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Derek C AngusDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine and UPMC Health System, Pittsburgh, PA, USA.
T Eoin WestInternational Respiratory and Severe Illness Center, University of Washington, Seattle, WA, USA.

Funding

RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Sepsis subtypes: biology, treatment, and bedside applicationR35GM119519 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christopher W. Seymour · 2016 to 2026
$4.9M
NHLBI NIH HHS T32 HL007287NIGMS NIH HHS R35 GM119519
6 · The paper itself

Abstract

Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.

Indexed as

Cost of IllnessDeveloping CountriesGlobal HealthHealth ResourcesHumansSepsisHealth resourcesLow-income countriesPovertyPublic healthSepsis

Identifiers

PMID30243300
PMCPMC6151187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.